All-transRetinoic Acid Regulates Th1/Th2 Balance in CD4+T cells When GATA-3 is Deficient

被引：0
|
作者：
ZHU Yan Feng [1 ]
HU Jia Zhe [2 ]
ZHAO Pin Nan [3 ]
LIU Lin Xi [1 ]
and LI Yun [1 ]
机构：
[1] Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University
来源：
BiomedicalandEnvironmentalSciences | 2013年 / 26卷 / 09期
基金：
中国国家自然科学基金;
关键词：
GATA; cell; Th; All-transRetinoic Acid Regulates Th1/Th2 Balance in CD4+T cells When GATA-3 is Deficient; CD;
D O I：
暂无
中图分类号：
R392.1 [免疫生物学];
学科分类号：
摘要：
The essential effect of vitamin A on immune function occurs through various mechanisms including direct effect on Th1-Th2 balance modulation.However,it is unclear whether or not vitamin A can regulate Th1-Th2 balance under a strong Th1-polarizing condition.Therefore,the purpose of our study was to examine the effect of vitamin A metabolite all-trans retinoic acid(ATRA)on Th1-Th2 differentiation in CD4+T cells under GATA-3 deficiency,which can induce Th1-polarizing condition.In the present study,GATA-3 deficiency T cells were induced by siRNA and checked by
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页码：774 / 777
页数：4
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