Effects of norepinephrine and isopentenyladenosine on Na~+/Ca2+ exchangecurrents in isolated guinea pig ventricular myocytes

被引：0

作者：

顿文 ^{[1
]}

吴博威 ^{[1
]}

赵荣瑞 ^{[1
]}

机构：

[1] 山西医科大学生理教研室

来源：

Acta Pharmacologica Sinica | 1998年 / 02期

关键词：

Na~＋／Ca2＋交换; 去甲肾上腺素; 异丙肾上腺素; 普萘洛尔; 酚妥拉明; 膜片箝技术; 心肌; 离子交换;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的：研究去甲肾上腺素（ＮＥ）和异丙肾上腺素（Ｉｓｏ）对Ｎａ＋／Ｃａ２＋交换电流的影响及受体调控机制．方法：应用全细胞电压钳技术的斜坡脉冲程序，测定离体豚鼠心肌细胞准稳态电流电压关系曲线．结果：ＮＥ０００５，００５和５μｍｏｌ·Ｌ－１分别使膜电位＋５０ｍＶ时的Ｎｉ２＋敏感电流增加２９％±９％，７２％±１１％和１２０％±３１％；Ｉｓｏ１５，１５０和１５００ｎｍｏｌ·Ｌ－１分别使该电流增加２８％±２８％，５６％±１３％和１０２％±１２％．ＮＥ和Ｉｓｏ的这种增强效应能被普萘洛尔１０μｍｏｌ·Ｌ－１完全阻断，而酚妥拉明５０μｍｏｌ·Ｌ－１无此作用．结论：ＮＥ和Ｉｓｏ通过兴奋心脏β肾上腺素受体使Ｎａ＋／Ｃａ２＋交换电流增加．

引用

页码：46 / 49

页数：4

共 50 条

[21] Mechanism of Na+/Ca2+ exchanger activation by hydrogen peroxide in guinea-pig ventricular myocytes
Hinata, Masamitsu
Matsuoka, Isao
Iwamoto, Takahiro
Watanabe, Yasuhide
Kimura, Junko
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103 (03) : 283 - 292
[22] FREE-RADICALS IRREVERSIBLY DECREASE CA2+ CURRENTS IN ISOLATED GUINEA-PIG VENTRICULAR MYOCYTES
GILL, JS
MCKENNA, WJ
CAMM, AJ
EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION, 1995, 292 (3-4): : 337 - 340
[23] Effects of hypoxia and metabolic inhibition on increases in intracellular Ca2+ concentration induced by Na+/Ca2+ exchange in isolated guinea-pig cardiac myocytes
Mochizuki, S
MacLeod, KT
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1997, 29 (11) : 2979 - 2987
[24] Effects of Glybenclamide on Na+-K+ pump and L-type Ca2+ channel in guinea-pig ventricular myocytes
Lee, SY
Lee, CO
BIOPHYSICAL JOURNAL, 2003, 84 (02) : 409A - 409A
[25] THE EFFECTS OF HYPOXIA ON CYTOPLASMIC CA2+ DURING LOW NA+ EXPOSURE IN ISOLATED CARDIAC MYOCYTES FROM GUINEA-PIG
MOCHIZUKI, S
MACLEOD, KT
JOURNAL OF PHYSIOLOGY-LONDON, 1992, 446 : P334 - P334
[26] β-adrenergic stimulation of the Na+-Ca2+ exchange in isolated guinea-pig ventricular myocytes at 37°C
Perchenet, L
Hinde, AKB
Patel, RCR
Pabbathi, VK
Hancox, JC
Levi, AJ
JOURNAL OF PHYSIOLOGY-LONDON, 1998, 509P : 140P - 141P
[27] Inhibitory Effect of Cibenzoline on Na+/Ca2+ Exchange Current in Guinea-Pig Cardiac Ventricular Myocytes
Yamakawa, Tomomi
Watanabe, Yasuhide
Watanabe, Hiroshi
Kimura, Junko
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 120 (01) : 59 - 62
[28] Activation mechanism of Na+/Ca2+ exchange by hydrogen peroxide in guinea-pig ventricular myocytes.
Hinata, M
Matsuoka, I
Kimura, J
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, 91 : 153P - 153P
[29] Modulation of the Na+/Ca2+ exchanger by isoprenaline, adenosine, and endothelin-1 in guinea pig ventricular myocytes
Zhang, YH
Hinde, AK
James, AF
Hancox, JC
CELLULAR AND MOLECULAR PHYSIOLOGY OF SODIUM-CALCIUM EXCHANGE, 2002, 976 : 535 - 538
[30] Inhibitory effect of aprindine on Na+/Ca2+ exchange current in guinea-pig cardiac ventricular myocytes
Watanabe, Y
Iwamoto, T
Shigekawa, M
Kimura, J
BRITISH JOURNAL OF PHARMACOLOGY, 2002, 136 (03) : 361 - 366

← 1 2 3 4 5 →