Effects of norepinephrine and isopentenyladenosine on Na~+/Ca2+ exchangecurrents in isolated guinea pig ventricular myocytes

被引：0

作者：

顿文 ^{[1
]}

吴博威 ^{[1
]}

赵荣瑞 ^{[1
]}

机构：

[1] 山西医科大学生理教研室

来源：

Acta Pharmacologica Sinica | 1998年 / 02期

关键词：

Na~＋／Ca2＋交换; 去甲肾上腺素; 异丙肾上腺素; 普萘洛尔; 酚妥拉明; 膜片箝技术; 心肌; 离子交换;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的：研究去甲肾上腺素（ＮＥ）和异丙肾上腺素（Ｉｓｏ）对Ｎａ＋／Ｃａ２＋交换电流的影响及受体调控机制．方法：应用全细胞电压钳技术的斜坡脉冲程序，测定离体豚鼠心肌细胞准稳态电流电压关系曲线．结果：ＮＥ０００５，００５和５μｍｏｌ·Ｌ－１分别使膜电位＋５０ｍＶ时的Ｎｉ２＋敏感电流增加２９％±９％，７２％±１１％和１２０％±３１％；Ｉｓｏ１５，１５０和１５００ｎｍｏｌ·Ｌ－１分别使该电流增加２８％±２８％，５６％±１３％和１０２％±１２％．ＮＥ和Ｉｓｏ的这种增强效应能被普萘洛尔１０μｍｏｌ·Ｌ－１完全阻断，而酚妥拉明５０μｍｏｌ·Ｌ－１无此作用．结论：ＮＥ和Ｉｓｏ通过兴奋心脏β肾上腺素受体使Ｎａ＋／Ｃａ２＋交换电流增加．

引用

页码：46 / 49

页数：4

共 50 条

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