Emerging molecular targets and therapy for cholangiocarcinoma

被引：0
|
作者：
Hamzeh Kayhanian [1 ]
Elizabeth C Smyth [1 ]
Chiara Braconi [1 ,2 ]
机构：
[1] Department of Gastrointestinal Oncology, Royal Marsden Hospital, London and Surrey SM2 5PT
[2] Institute of Cancer Research, London and Surrey SM2 5PT
来源：
World Journal of Gastrointestinal Oncology | 2017年 / 07期
关键词：
Cholangiocarcinoma; Biliary tract cancer; Targeted therapy; immunotherapy; Mutation; Molecular; Microenvironment; Stroma; MiRNA;
D O I：
暂无
中图分类号：
R735.8 [胆囊、胆道肿瘤];
学科分类号：
100214 ;
摘要：
Cholangiocarcinoma(CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic landscape of CCA and examine results from trials of molecularly targeted agents and immunotherapy in this disease. Challenges in CCA diagnosis, treatment and trial design are discussed and we reflect on future directions which may lead to improved outcomes for CCA patients.
引用
收藏
页码：268 / 280
页数：13
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