Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy: demographic, virological, and clinical features

被引：1

作者：

Coppola Nicola

Alessio Loredana ^{[1
,2
]}

Gualdieri Luciano ^{[3
]}

Pisaturo Mariantonietta ^{[4
,5
]}

Sagnelli Caterina ^{[6
,7
]}

Minichini Carmine ^{[1
]}

Di Caprio Giovanni ^{[1
,2
]}

Starace Mario ^{[1
]}

Onorato Lorenzo ^{[1
,2
]}

Signoriello Giuseppe ^{[8
]}

Macera Margherita ^{[1
]}

Angelillo Italo Francesco ^{[9
]}

Pasquale Giuseppe ^{[1
]}

Sagnelli Evangelista ^{[5
]}

机构：

[1] DepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,SecondUniversityofNaples,ViaL.Armanni5,80133Naples,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,SecondUniversityofNaples,ViaL.Armanni5,80133Naples,Italy

[2] MedicalCenter,Socialcenter"exCanapificio",Caserta,ItalyMedicalCenter,Centerforthewardshipoftheimmigrants,Naples,ItalyMedicalCenter,Welcomecenter’LatendadiAbramo’,Caserta,Italy

[3] InfectiousDiseasesUnit,AORNSant’AnnaeSanSebastiano,Caserta,ItalyDepartmentofClinicalandExperimentalMedicineandSurgery,SecondUniversityofNaples,Naples,Italy

[4] Medicalcenter,Centerofmissionarynunsofcarithy,Naples,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,SecondUniversityofNaples,ViaL.Armanni5,80133Naples,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,Se

[5] MedicalCenter,Socialcenter"exCanapificio",Caserta,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,SecondUniversityofNaples,ViaL.Armanni5,80133Naples,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,Secon

[6] MedicalCenter,Socialcenter"exCanapificio",Caserta,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofStatistic,SecondUniversityofNaples,Naples,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,SecondUniversityofNaples,ViaL.Arm

来源：

贫困所致传染病(英文) | 2017年 / 01期

关键词：

Hepatitis B; Chronic hepatitis B virus infection; Immigration; Illegal immigrants; Refugees; Italy;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Background: The data on hepatitis b virus (HBV) infection in immigrants population are scanty. The porpoise of this study was to define the demographic, virological, and clinical characteristics of subjects infected with HBV chronic infection in a cohort of immigrants living in Naples, Italy.Methods: A screening for HBV infection was offered to 1,331 immigrants, of whom 1,212 (91%) (831 undocumented immigrants and 381 refugees) accepted and were screened for hepatitis B surface antigen (HBsAg) and anti-hepatitis B core antibody (HBc). Those found to be HBsAg positive were further investigated at third-level infectious disease units.Results: Of the 1,212 immigrants screened, 116 (9.6%) were HBsAg positive, 490 (40.4%) were HBsAg negative/anti-HBc positive, and 606 (50%) were seronegative for both. Moreover, 21 (1.7%) were anti-human immunodeficiency virus positive and 45 (3.7%) were anti-hepatitis C virus positive. The logistic regression analysis showed that male sex (OR: 1.79; 95%CI: 1.28–2.51), Sub-Saharan African origin (OR: 6.18; 95%CI: 3.37–11.36), low level of schooling (OR: 0.96; 95%CI: 0.94–0.99), and minor parenteral risks for acquiring HBV infection (acupuncture, tattoo, piercing, or tribal practices,OR: 1.54; 95%CI: 1.1–2.16) were independently associated with ongoing or past HBV infection. Of the 116 HBsAg-positive immigrants, 90 (77.6%) completed their diagnostic itinerary at a third-level infectious disease unit: 29 (32.2%) were asymptomatic non-viremic HBsAg carriers, 43 (47.8%) were asymptomatic viremic carriers, 14 (15.6%) had chronic hepatitis, and four (4.4%) had liver cirrhosis, with superimposed hepatocellular carcinoma in two.Conclusions: The data illustrate the demographic, clinical and virological characteristics of HBV infection in immigrants in Italy and indicate the need for Italian healthcare authorities to enhance their support for providing screening, HBV vaccination, treatment, and educational programs for this populations.

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页码：58 / 59-60-61-62-63-64-65-66

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[11] The long-term benefits of nucleos(t)ide analogs in compensated HBV cirrhotic patients with no or small esophageal varices: A 12-year prospective cohort study[J] . Pietro Lampertico,Federica Invernizzi,Mauro Viganò,Alessandro Loglio,Giampaolo Mangia,Floriana Facchetti,Massimo Primignani,Manol Jovani,Massimo Iavarone,Mirella Fraquelli,Giovanni Casazza,Roberto de Franchis,Massimo Colombo. &nbspJournal of Hepatology . 2015 (5)
[12] The long-term benefits of nucleos(t)ide analogs in compensated HBV cirrhotic patients with no or small esophageal varices: A 12-year prospective cohort study[J] . Pietro Lampertico,Federica Invernizzi,Mauro Viganò,Alessandro Loglio,Giampaolo Mangia,Floriana Facchetti,Massimo Primignani,Manol Jovani,Massimo Iavarone,Mirella Fraquelli,Giovanni Casazza,Roberto de Franchis,Massimo Colombo. &nbspJournal of Hepatology . 2015 (5)
[13] Hepatitis B virus intergenotypic recombinants worldwide: An overview[J] . Natalia M. Araujo. &nbspInfection, Genetics and Evolution . 2015
[14] Hepatitis B virus intergenotypic recombinants worldwide: An overview[J] . Natalia M. Araujo. &nbspInfection, Genetics and Evolution . 2015
[15] AASLD guidelines for treatment of chronic hepatitis B
Terrault, Norah A.
Bzowej, Natalie H.
Chang, Kyong-Mi
Hwang, Jessica P.
Jonas, Maureen M.
Murad, M. Hassan
[J]. HEPATOLOGY, 2016, 63 (01) : 261 - 283
[16] AASLD guidelines for treatment of chronic hepatitis B
Terrault, Norah A.
Bzowej, Natalie H.
Chang, Kyong-Mi
Hwang, Jessica P.
Jonas, Maureen M.
Murad, M. Hassan
[J]. HEPATOLOGY, 2016, 63 (01) : 261 - 283
[17] Impact of comorbidities on the severity of chronic hepatitis B at presentation[J]. Evangelista Sagnelli,Tommaso Stroffolini,Alfonso Mele,Michele Imparato,Caterina Sagnelli,Nicola Coppola,Piero Luigi Almasio. World Journal of Gastroenterology. 2012(14)
[18] Impact of comorbidities on the severity of chronic hepatitis B at presentation[J]. Evangelista Sagnelli,Tommaso Stroffolini,Alfonso Mele,Michele Imparato,Caterina Sagnelli,Nicola Coppola,Piero Luigi Almasio. World Journal of Gastroenterology. 2012(14)
[19] Management of hepatocellular carcinoma: Enlightening the gray zones[J]. Andrea Mancuso. World Journal of Hepatology. 2013(06)
[20] Management of hepatocellular carcinoma: Enlightening the gray zones[J]. Andrea Mancuso. World Journal of Hepatology. 2013(06)

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