Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy: demographic, virological, and clinical features

被引：1

作者：

Coppola Nicola

Alessio Loredana ^{[1
,2
]}

Gualdieri Luciano ^{[3
]}

Pisaturo Mariantonietta ^{[4
,5
]}

Sagnelli Caterina ^{[6
,7
]}

Minichini Carmine ^{[1
]}

Di Caprio Giovanni ^{[1
,2
]}

Starace Mario ^{[1
]}

Onorato Lorenzo ^{[1
,2
]}

Signoriello Giuseppe ^{[8
]}

Macera Margherita ^{[1
]}

Angelillo Italo Francesco ^{[9
]}

Pasquale Giuseppe ^{[1
]}

Sagnelli Evangelista ^{[5
]}

机构：

[1] DepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,SecondUniversityofNaples,ViaL.Armanni5,80133Naples,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,SecondUniversityofNaples,ViaL.Armanni5,80133Naples,Italy

[2] MedicalCenter,Socialcenter"exCanapificio",Caserta,ItalyMedicalCenter,Centerforthewardshipoftheimmigrants,Naples,ItalyMedicalCenter,Welcomecenter’LatendadiAbramo’,Caserta,Italy

[3] InfectiousDiseasesUnit,AORNSant’AnnaeSanSebastiano,Caserta,ItalyDepartmentofClinicalandExperimentalMedicineandSurgery,SecondUniversityofNaples,Naples,Italy

[4] Medicalcenter,Centerofmissionarynunsofcarithy,Naples,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,SecondUniversityofNaples,ViaL.Armanni5,80133Naples,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,Se

[5] MedicalCenter,Socialcenter"exCanapificio",Caserta,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,SecondUniversityofNaples,ViaL.Armanni5,80133Naples,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,Secon

[6] MedicalCenter,Socialcenter"exCanapificio",Caserta,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofStatistic,SecondUniversityofNaples,Naples,ItalyDepartmentofMentalHealthandPublicMedicine,SectionofInfectiousDiseases,SecondUniversityofNaples,ViaL.Arm

来源：

贫困所致传染病(英文) | 2017年 / 01期

关键词：

Hepatitis B; Chronic hepatitis B virus infection; Immigration; Illegal immigrants; Refugees; Italy;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Background: The data on hepatitis b virus (HBV) infection in immigrants population are scanty. The porpoise of this study was to define the demographic, virological, and clinical characteristics of subjects infected with HBV chronic infection in a cohort of immigrants living in Naples, Italy.Methods: A screening for HBV infection was offered to 1,331 immigrants, of whom 1,212 (91%) (831 undocumented immigrants and 381 refugees) accepted and were screened for hepatitis B surface antigen (HBsAg) and anti-hepatitis B core antibody (HBc). Those found to be HBsAg positive were further investigated at third-level infectious disease units.Results: Of the 1,212 immigrants screened, 116 (9.6%) were HBsAg positive, 490 (40.4%) were HBsAg negative/anti-HBc positive, and 606 (50%) were seronegative for both. Moreover, 21 (1.7%) were anti-human immunodeficiency virus positive and 45 (3.7%) were anti-hepatitis C virus positive. The logistic regression analysis showed that male sex (OR: 1.79; 95%CI: 1.28–2.51), Sub-Saharan African origin (OR: 6.18; 95%CI: 3.37–11.36), low level of schooling (OR: 0.96; 95%CI: 0.94–0.99), and minor parenteral risks for acquiring HBV infection (acupuncture, tattoo, piercing, or tribal practices,OR: 1.54; 95%CI: 1.1–2.16) were independently associated with ongoing or past HBV infection. Of the 116 HBsAg-positive immigrants, 90 (77.6%) completed their diagnostic itinerary at a third-level infectious disease unit: 29 (32.2%) were asymptomatic non-viremic HBsAg carriers, 43 (47.8%) were asymptomatic viremic carriers, 14 (15.6%) had chronic hepatitis, and four (4.4%) had liver cirrhosis, with superimposed hepatocellular carcinoma in two.Conclusions: The data illustrate the demographic, clinical and virological characteristics of HBV infection in immigrants in Italy and indicate the need for Italian healthcare authorities to enhance their support for providing screening, HBV vaccination, treatment, and educational programs for this populations.

引用

页码：58 / 59-60-61-62-63-64-65-66

共 95 条

[1] Serologic markers for HBV, HCV and HIV in immigrants visiting the Athens’ polyclinic of ‘Doctors of the World – Greece’[J] . G. Papadakis,N.A. Okoba,C. Nicolaou,F. Boufidou,A. Ioannidis,S. Bersimis,S. Chatzipanagiotou. &nbspPublic Health . 2013 (11)
[2] Serologic markers for HBV, HCV and HIV in immigrants visiting the Athens’ polyclinic of ‘Doctors of the World – Greece’[J] . G. Papadakis,N.A. Okoba,C. Nicolaou,F. Boufidou,A. Ioannidis,S. Bersimis,S. Chatzipanagiotou. &nbspPublic Health . 2013 (11)
[3] Clinical and virological characteristics associated with severe acute hepatitis B
Coppola, N.
Sagnelli, C.
Pisaturo, M.
Minichini, C.
Messina, V.
Alessio, L.
Starace, M.
Signoriello, G.
Gentile, I.
Filippini, P.
Sagnelli, E.
[J]. CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 (12) : O991 - O997
[4] Clinical and virological characteristics associated with severe acute hepatitis B
Coppola, N.
Sagnelli, C.
Pisaturo, M.
Minichini, C.
Messina, V.
Alessio, L.
Starace, M.
Signoriello, G.
Gentile, I.
Filippini, P.
Sagnelli, E.
[J]. CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 (12) : O991 - O997
[5] TM 6 SF 2 E167K variant is associated with severe steatosis in chronic hepatitis C, regardless of PNPLA 3 polymorphism[J] . Nicola Coppola,Zampino Rosa,Grazia Cirillo,Maria Stanzione,Margherita Macera,Adriana Boemio,Anna Grandone,Mariantonietta Pisaturo,Aldo Marrone,Luigi E. Adinolfi,Evangelista Sagnelli,Emanuele Miraglia del Giudice. &nbspLiver Int . 2015 (8)
[6] TM 6 SF 2 E167K variant is associated with severe steatosis in chronic hepatitis C, regardless of PNPLA 3 polymorphism[J] . Nicola Coppola,Zampino Rosa,Grazia Cirillo,Maria Stanzione,Margherita Macera,Adriana Boemio,Anna Grandone,Mariantonietta Pisaturo,Aldo Marrone,Luigi E. Adinolfi,Evangelista Sagnelli,Emanuele Miraglia del Giudice. &nbspLiver Int . 2015 (8)
[7] Estimating HIV Incidence, Time to Diagnosis, and the Undiagnosed HIV Epidemic Using Routine Surveillance Data[J] . Ard van Sighem,Fumiyo Nakagawa,Daniela De Angelis,Chantal Quinten,Daniela Bezemer,Eline Op de Coul,Matthias Egger,Frank de Wolf,Christophe Fraser,Andrew Phillips. &nbspEpidemiology . 2015 (5)
[8] Estimating HIV Incidence, Time to Diagnosis, and the Undiagnosed HIV Epidemic Using Routine Surveillance Data[J] . Ard van Sighem,Fumiyo Nakagawa,Daniela De Angelis,Chantal Quinten,Daniela Bezemer,Eline Op de Coul,Matthias Egger,Frank de Wolf,Christophe Fraser,Andrew Phillips. &nbspEpidemiology . 2015 (5)
[9] Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study[J] . N. Tozun,O. Ozdogan,Y. Cakaloglu,R. Idilman,Z. Karasu,U. Akarca,S. Kaymakoglu,O. Ergonul. &nbspClinical Microbiology and Infection . 2015 (11)
[10] Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study[J] . N. Tozun,O. Ozdogan,Y. Cakaloglu,R. Idilman,Z. Karasu,U. Akarca,S. Kaymakoglu,O. Ergonul. &nbspClinical Microbiology and Infection . 2015 (11)

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