A novel synthetic route for 2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanamine

被引：0
|
作者：
Xiao Chuan Luo~(a
机构：
来源：
ChineseChemicalLetters | 2008年 / 01期
关键词：
Silodosin; 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethanamine; Synthesis;
D O I：
暂无
中图分类号：
O621.3 [有机合成化学];
学科分类号：
摘要：
2-[2-（2,2,2-Trifluoroethoxy）phenoxy]ethanamine is the key intermediate of Silodosin,theα;-adrenoceptor antagonist for the treatment of benign prostatic hyperplasia.In order to obtain this intermediate,we developed a novel synthetic route by utilizing 2- nitrochlorobenzene as the starting material via O-alkylation,reduction,diazotization,acidolysis,etherification,condensation and hydrazinolysis.The highlight of this method lies on its convenience and economy in accessing this intermediate.
引用
收藏
页码：59 / 60
页数：2
相关论文
共 50 条
  • [31] 2-[2-(cyanomethoxy)phenoxy]acetonitrile
    Ustabas, R
    Çoruh, U
    Sancak, K
    Er, M
    Ünver, Y
    Yavuz, M
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2004, 60 : O968 - O970
  • [32] 5,5′-Bis[(2,2,2-trifluoroethoxy)methyl]-2,2′-bipyridine
    Lu, Norman
    Tu, Wen-Han
    Chang, Wei-Hsuan
    Wu, Zong-Wei
    Su, Han-Chang
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O355 - U515
  • [33] 2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methylsulfanyl}-1H-benzimidazole monohydrate: a monoclinic polymorph
    Chen, Yu-Feng
    Chen, Jin-Yao
    Hong, Ming-Huang
    Lu, Jie
    Ren, Guo-Bin
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O2015 - +
  • [34] PREPARATION AND REACTIONS OF (2-CHLOROETHOXY)TRICHLOROTITANIUM(IV) AND (2,2,2-TRIFLUOROETHOXY)-TRICHLOROTITANIUM(IV)
    PAUL, RC
    SHARMA, P
    GUPTA, PK
    CHADHA, SL
    INORGANICA CHIMICA ACTA, 1976, 20 (01) : 7 - 9
  • [35] FACILE SYNTHESIS OF UNSYMMETRICAL SULFIDES USING BIS(2,2,2-TRIFLUOROETHOXY)TRIPHENYLPHOSPHORANE
    KUBOTA, T
    MIYASHITA, S
    KITAZUME, T
    ISHIKAWA, N
    CHEMISTRY LETTERS, 1979, (07) : 845 - 846
  • [36] 2-[2-(hydroxyethyl)phenoxy]benzoic acid
    Damas, AM
    Roleira, FF
    Pinto, MMM
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1997, 53 : 1143 - 1145
  • [37] 2,2,2-Trifluoroethoxy Aromatic Heterocycles: Hydrolytically Stable Alternatives to Heteroaryl Chlorides
    Fisher, Ethan L.
    Ende, Christopher W. Am
    Humphrey, John M.
    JOURNAL OF ORGANIC CHEMISTRY, 2019, 84 (08): : 4904 - 4909
  • [38] KINETICS OF THERMAL-DEGRADATION OF POLY[BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHAZENE]
    ZELDIN, M
    JO, WH
    PEARCE, EM
    MACROMOLECULES, 1980, 13 (05) : 1163 - 1167
  • [39] THE EFFECT OF FLUROXENE [(2,2,2-TRIFLUOROETHOXY)ETHANE] ON HEME-BIOSYNTHESIS AND DEGRADATION
    ZIMAN, MR
    BRADSHAW, JJ
    IVANETICH, KM
    BIOCHEMICAL JOURNAL, 1980, 190 (03) : 571 - 580
  • [40] BIS(1-TRIFLUOROMETHYL-2,2,2-TRIFLUOROETHOXY)TRIPHENYLPHOSPHORANE - A NEW ROUTE TO TRIFLUOROMETHYLATED HETEROCYCLES
    KUBOTA, T
    YAMAMOTO, K
    TANAKA, T
    CHEMISTRY LETTERS, 1983, (02) : 167 - 168
12345