A novel synthetic route for 2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanamine

被引：0
|
作者：
Xiao Chuan Luo~(a
机构：
来源：
ChineseChemicalLetters | 2008年 / 01期
关键词：
Silodosin; 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethanamine; Synthesis;
D O I：
暂无
中图分类号：
O621.3 [有机合成化学];
学科分类号：
摘要：
2-[2-（2,2,2-Trifluoroethoxy）phenoxy]ethanamine is the key intermediate of Silodosin,theα;-adrenoceptor antagonist for the treatment of benign prostatic hyperplasia.In order to obtain this intermediate,we developed a novel synthetic route by utilizing 2- nitrochlorobenzene as the starting material via O-alkylation,reduction,diazotization,acidolysis,etherification,condensation and hydrazinolysis.The highlight of this method lies on its convenience and economy in accessing this intermediate.
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页码：59 / 60
页数：2
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