STUDIES ON THE STRUCTURE-FUNCTION RELATIONSHIPS OF INSULIN Ⅰ. THE RELATIONSHIP OF THE C-TERMINAL PEPTIDE SEQUENCE OF B-CHAIN TO THE ACTIVITY OF INSULIN

被引：0

作者：

The Shanghai Insulin Research Group ^{[1
]}

机构：

[1] 上海胰岛素研究小组

来源：

Science China Mathematics | 1973年 / 01期

关键词：

STUDIES ON THE STRUCTURE-FUNCTION RELATIONSHIPS OF INSULIN; THE RELATIONSHIP OF THE C-TERMINAL PEPTIDE SEQUENCE OF B-CHAIN TO THE ACTIVITY OF INSULIN;

D O I：

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学科分类号：

摘要：

Desoctapeptide insulin, obtained as a product from the tryptie digestion of natural insulin, has been condensed with the synthetic C-terminal octapcptide to regenerate insulin.Deshexapeptide insulin was obtained when glyeylphenylalanine was condensed with desoctapeptide insulin. It was found to possess insulin activtiy, indicating that Bglycine and Bphenylalanine are both essential to biological activity.

引用

页码：61 / 70

页数：10

共 50 条

[1] STUDIES ON THE STRUCTURE-FUNCTION RELATIONSHIPS OF INSULIN Ⅰ. THE RELATIONSHIP OF THE C-TERMINAL PEPTIDE SEQUENCE OF B-CHAIN TO THE ACTIVITY OF INSULIN
The Shanghai Insulin Research Group
ScienceinChina,SerA., 1973, Ser.A.1973 (01) : 61 - 70
[2] SYNTHESIS OF THE PEPTIDE FRAGMENTS OF THE B-CHAIN OF INSULIN——Ⅴ.STUDIES ON THE SYNTHESIS AND DEGRADATION OF A DERIVATIVE OF THE C-TERMINAL DECAPEPTIDE OF THE B-CHAIN OF INSULIN
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[3] SYNTHESIS OF PEPTIDE FRAGMENTS OF B-CHAIN OF INSULIN .5. STUDIES ON SYNTHESIS AND DEGRADATION OF A DERIVATIVE OF C-TERMINAL DECAPETIDE OF B-CHAIN OF INSULIN
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[4] SYNTHESIS OF PEPTIDE FRAGMENTS OF B-CHAIN OF INSULIN .10. SYNTHESIS OF A DERIVATIVE OF C-TERMINAL DOCOSAPEPTIDE OF B-CHAIN OF INSULIN
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[5] SYNTHESIS OF PEPTIDE FRAGMENTS OF B-CHAIN OF INSULIN .7. SYNTHESIS OF DERIVATIVE OF C-TERMINAL TETRADECA-PEPTIDE OF B-CHAIN OF INSULIN
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[6] SYNTHESIS OF THE C-TERMINAL DECAPEPTIDE OF BOVINE INSULIN B-CHAIN
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HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1979, 360 (12): : 1775 - 1781
[7] INSULIN PEPTIDES .8. A SYNTHETIC HEPTADECAPEPTIDE DERIVATIVE CORRESPONDING TO C-TERMINAL SEQUENCE OR B-CHAIN OF INSULIN
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[8] INSULIN PEPTIDES .3. SYNTHESIS OF A PROTECTED NONAPEPTIDE CONTAINING C-TERMINAL SEQUENCE OF B-CHAIN INSULIN
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[9] PREPARATION AND CRYSTALLIZATION OF DES (B-CHAIN C-TERMINAL) HEPTAPEPTIDE INSULIN
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Science China Mathematics, 1980, (12) : 1592 - 1598
[10] PREPARATION AND CRYSTALLIZATION OF DES (B-CHAIN C-TERMINAL) HEPTAPEPTIDE INSULIN
LU, ZI
YU, RH
SCIENTIA SINICA, 1980, 23 (12): : 1592 - 1598

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