tmRNA,a combination of a tRNA-related fragment and a small mRNA fragment,was confirmed as the integration site of genomic islands(GIs).Using sequence alignment and comparative genomics,68 GIs associated with tmRNA genes were identified among 13 genera of Enterobacteriaceae.Among them,53 GIs were found in Escherichia coli and Salmonella enterica.Among these 53 GIs,tandem GIs were verified in eight S.enterica and two E.coli chromosomes.The downstream regions of the tmRNA genes in most of the E.coli and S.enterica chromosomes include one GI or tandem GIs region and a remnant variable region distal to the tmRNA.The chronology of integration of tandem GIs into the genome indicated that GIs farther from the tmRNA were incorporated into the genome earlier than those nearer from the tmRNA.The integrases of the tmRNA gene-associated GIs can be further categorized into three subtypes:HP1 integrases,PhiCTX integrases,and P4 integrases,which are the most predominant.The GIs were first integrated into the chromosome by the P4 integrase,subsequently by the PhiCTX integrase,and finally by the HP1 integrase.Thus,the tmRNA gene is an important site for investigating the genetics and evolution of tandem GIs.
机构:
Univ Chile, Fac Med, Inst Ciencias Biomed, Programa Microbil & Micol, Santiago 8380453, Chile
Univ Santiago Chile, Fac Quim & Biol, Santiago, ChileUniv Chile, Fac Med, Inst Ciencias Biomed, Programa Microbil & Micol, Santiago 8380453, Chile
Del Canto, Felipe
Valenzuela, Patricio
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Univ Santiago Chile, Fac Quim & Biol, Santiago, ChileUniv Chile, Fac Med, Inst Ciencias Biomed, Programa Microbil & Micol, Santiago 8380453, Chile
Valenzuela, Patricio
Cantero, Lidia
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机构:
Univ Santiago Chile, Fac Quim & Biol, Santiago, ChileUniv Chile, Fac Med, Inst Ciencias Biomed, Programa Microbil & Micol, Santiago 8380453, Chile
Cantero, Lidia
Bronstein, Jonathan
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机构:
Univ Santiago Chile, Fac Quim & Biol, Santiago, ChileUniv Chile, Fac Med, Inst Ciencias Biomed, Programa Microbil & Micol, Santiago 8380453, Chile
Bronstein, Jonathan
Blanco, Jesus E.
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机构:
Univ Santiago Compostela, Fac Vet, Lab Referencia E Coli, Lugo, SpainUniv Chile, Fac Med, Inst Ciencias Biomed, Programa Microbil & Micol, Santiago 8380453, Chile
Blanco, Jesus E.
Blanco, Jorge
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机构:
Univ Santiago Compostela, Fac Vet, Lab Referencia E Coli, Lugo, SpainUniv Chile, Fac Med, Inst Ciencias Biomed, Programa Microbil & Micol, Santiago 8380453, Chile
Blanco, Jorge
Prado, Valeria
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Univ Santiago Chile, Fac Quim & Biol, Santiago, ChileUniv Chile, Fac Med, Inst Ciencias Biomed, Programa Microbil & Micol, Santiago 8380453, Chile
Prado, Valeria
Levine, Myron
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h-index: 0
机构:
Univ Maryland, Ctr Vaccine Dev, Baltimore, MD 21201 USAUniv Chile, Fac Med, Inst Ciencias Biomed, Programa Microbil & Micol, Santiago 8380453, Chile
Levine, Myron
Nataro, James
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Univ Maryland, Ctr Vaccine Dev, Baltimore, MD 21201 USAUniv Chile, Fac Med, Inst Ciencias Biomed, Programa Microbil & Micol, Santiago 8380453, Chile
Nataro, James
Sommerfelt, Halvor
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h-index: 0
机构:
Univ Bergen, Ctr Int Hlth, Bergen, NorwayUniv Chile, Fac Med, Inst Ciencias Biomed, Programa Microbil & Micol, Santiago 8380453, Chile
Sommerfelt, Halvor
Vidal, Roberto
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Univ Santiago Chile, Fac Quim & Biol, Santiago, ChileUniv Chile, Fac Med, Inst Ciencias Biomed, Programa Microbil & Micol, Santiago 8380453, Chile
机构:
EMBL European Bioinformat Inst, Cambridge CB10 1SD, England
Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, EnglandEMBL European Bioinformat Inst, Cambridge CB10 1SD, England
Prieto, Ana I.
Kahramanoglou, Christina
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机构:
Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England
Natl Inst Med Res, MRC, London NW7 1AA, EnglandEMBL European Bioinformat Inst, Cambridge CB10 1SD, England
Kahramanoglou, Christina
Ali, Ruhi M.
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h-index: 0
机构:
EMBL European Bioinformat Inst, Cambridge CB10 1SD, England
Anna Univ, Ctr Biotechnol, Madras 600035, Tamil Nadu, IndiaEMBL European Bioinformat Inst, Cambridge CB10 1SD, England
Ali, Ruhi M.
Fraser, Gillian M.
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h-index: 0
机构:
Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, EnglandEMBL European Bioinformat Inst, Cambridge CB10 1SD, England
Fraser, Gillian M.
Seshasayee, Aswin S. N.
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h-index: 0
机构:
EMBL European Bioinformat Inst, Cambridge CB10 1SD, England
GKVK, Natl Ctr Biol Sci, Bangalore 560065, Karnataka, IndiaEMBL European Bioinformat Inst, Cambridge CB10 1SD, England
Seshasayee, Aswin S. N.
Luscombe, Nicholas M.
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h-index: 0
机构:
EMBL European Bioinformat Inst, Cambridge CB10 1SD, England
Okinawa Inst Sci & Technol, Onna Son, Okinawa 9040495, JapanEMBL European Bioinformat Inst, Cambridge CB10 1SD, England
机构:
Ctr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USACtr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Lindsey, Rebecca L.
Batra, Dhwani
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h-index: 0
机构:
Ctr Dis Control & Prevent, Biotechnol Core Facil Branch, Div Sci Resources, Atlanta, GA USACtr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Batra, Dhwani
Smith, Peyton
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Oak Ridge Inst Sci & Educ, Oak Ridge, TN USACtr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Smith, Peyton
Patel, Pooja N.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Oak Ridge Inst Sci & Educ, Oak Ridge, TN USACtr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Patel, Pooja N.
Tagg, Kaitlin A.
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h-index: 0
机构:
IHRC Inc, Atlanta, GA USACtr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Tagg, Kaitlin A.
Garcia-Toledo, Lisley
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机构:
Ctr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Oak Ridge Inst Sci & Educ, Oak Ridge, TN USACtr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Garcia-Toledo, Lisley
Loparev, Vladimir N.
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机构:
Ctr Dis Control & Prevent, Biotechnol Core Facil Branch, Div Sci Resources, Atlanta, GA USACtr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Loparev, Vladimir N.
Juieng, Phalasy
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h-index: 0
机构:
Ctr Dis Control & Prevent, Biotechnol Core Facil Branch, Div Sci Resources, Atlanta, GA USACtr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Juieng, Phalasy
Sheth, Mill
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h-index: 0
机构:
Ctr Dis Control & Prevent, Biotechnol Core Facil Branch, Div Sci Resources, Atlanta, GA USACtr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Sheth, Mill
Joung, Yoo Jin
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h-index: 0
机构:
Ctr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Oak Ridge Inst Sci & Educ, Oak Ridge, TN USACtr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
Joung, Yoo Jin
Rowe, Lori A.
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机构:
Ctr Dis Control & Prevent, Biotechnol Core Facil Branch, Div Sci Resources, Atlanta, GA USACtr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA
机构:
Qingdao Agr Univ, Coll Vet Med, Qingdao, Peoples R China
Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, Frederiksberg, DenmarkQingdao Agr Univ, Coll Vet Med, Qingdao, Peoples R China
Liu, Gang
Kragh, Martin Laage
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机构:
Tech Univ Denmark, Natl Food Inst, Lyngby, DenmarkQingdao Agr Univ, Coll Vet Med, Qingdao, Peoples R China
Kragh, Martin Laage
Aabo, Soren
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机构:
Tech Univ Denmark, Natl Food Inst, Lyngby, DenmarkQingdao Agr Univ, Coll Vet Med, Qingdao, Peoples R China
Aabo, Soren
Jensen, Annette Nygaard
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机构:
Tech Univ Denmark, Natl Food Inst, Lyngby, DenmarkQingdao Agr Univ, Coll Vet Med, Qingdao, Peoples R China
Jensen, Annette Nygaard
Olsen, John Elmerdahl
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机构:
Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, Frederiksberg, DenmarkQingdao Agr Univ, Coll Vet Med, Qingdao, Peoples R China