DeSUMOylation of protein kinase B1inhibits cell proliferation and metastasis of hepatocellular carcinoma

被引：0
|
作者：
盛凤 [1 ]
机构：
[1] TCM Dept,5th Centr Hosp
来源：
China Medical Abstracts(Internal Medicine) | 2018年 / 35卷 / 01期
关键词：
HCC; DeSUMOylation of protein kinase B1inhibits cell proliferation and metastasis of hepatocellular carcinoma;
D O I：
暂无
中图分类号：
R735.7 [肝肿瘤];
学科分类号：
摘要：
Objective To investigate the effect of AKT1 deSUMOylation induced by Ubc9 silencing on the proliferation and metastasis of hepatocellular carcinoma(HCC)cells.Methods The Ubc9 gene was silenced using RNA interference,and the expression levels of Ubc9,SUMO1 and AKT1 protein were detected by Western blot.Cell proliferation and cell cycle was analyzed by MTT and flow
引用
收藏
页码：49 / 49
页数：1
相关论文
共 50 条
  • [41] Sodium selenite inhibits proliferation and metastasis through ROS‐mediated NF‐κB signaling in renal cell carcinoma
    Xiao Liu
    Meng Jiang
    Chenggang Pang
    Jianning Wang
    Lijuan Hu
    BMC Cancer, 22
  • [42] Knockdown of SKA1 gene inhibits cell proliferation and metastasis in human adenoid cystic carcinoma
    Zhao, Li-juan
    Yang, Hong-li
    Li, Ke-yi
    Gao, Yue-hua
    Dong, Kai
    Liu, Zhong-hao
    Wang, Le-xin
    Zhang, Bin
    BIOMEDICINE & PHARMACOTHERAPY, 2017, 90 : 8 - 14
  • [43] miR-206 inhibits cell proliferation, invasion, and migration by down-regulating PTP1B in hepatocellular carcinoma
    Yang, Qian
    Zhang, Lunli
    Zhong, Yuanbin
    Lai, Lingling
    Li, Xiaopeng
    BIOSCIENCE REPORTS, 2019, 39
  • [44] SF3B4 is regulated by microRNA-133b and promotes cell proliferation and metastasis in hepatocellular carcinoma
    Liu, Zhiyong
    Li, Wei
    Pang, Yanan
    Zhou, Zaixin
    Liu, Shupeng
    Cheng, Kai
    Qin, Qin
    Jia, Yin
    Liu, Shanrong
    EBIOMEDICINE, 2018, 38 : 57 - 68
  • [45] Schisantherin A inhibits cell proliferation by regulating glucose metabolism pathway in hepatocellular carcinoma
    Feng, Fan
    Pan, Lianhong
    Wu, Jiaqin
    Liu, Mingying
    He, Long
    Yang, Li
    Zhou, Wei
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [46] Paraoxonase 3 inhibits cell proliferation and serves as a prognostic predictor in hepatocellular carcinoma
    Cai, Jie
    Yuan, Sheng-Xian
    Yang, Fu
    Tao, Qi-Fei
    Yang, Yuan
    Xu, Qing-Guo
    Wang, Zhen-Guang
    Yu, Jian
    Lin, Kong-Ying
    Wang, Zong-Yan
    Ma, Jin-Zhao
    Zhou, Chuan-Chuan
    Wang, Fang
    Sun, Shu-Han
    Zhou, Wei-Ping
    ONCOTARGET, 2016, 7 (43) : 70045 - 70057
  • [47] miR-195 inhibits cell proliferation via targeting AEG-1 in hepatocellular carcinoma
    Yan, Jing-Jun
    Chang, Ying
    Zhang, Yu-Nan
    Lin, Ju-Sheng
    He, Xing-Xing
    Huang, Huan-Jun
    ONCOLOGY LETTERS, 2017, 13 (05) : 3118 - 3126
  • [48] microRNA-4270-5p inhibits cancer cell proliferation and metastasis in hepatocellular carcinoma by targeting SATB2
    Wang, Yun
    Li, Chang-feng
    Sun, Li-bo
    Li, Yong-chao
    HUMAN CELL, 2020, 33 (04) : 1155 - 1164
  • [49] microRNA-4270-5p inhibits cancer cell proliferation and metastasis in hepatocellular carcinoma by targeting SATB2
    Yun Wang
    Chang-feng Li
    Li-bo Sun
    Yong-chao Li
    Human Cell, 2020, 33 : 1155 - 1164
  • [50] Knockdown of golgi phosphoprotein 2 inhibits hepatocellular carcinoma cell proliferation and motility
    Liu, Yiming
    Zhang, Xiaodi
    Sun, Ting
    Jiang, Junchang
    Li, Ying
    Chen, Mingliang
    Wei, Zhen
    Jiang, Weiqin
    Zhou, Linfu
    ONCOTARGET, 2016, 7 (16) : 21404 - 21415
12345