Regulation of canonical Wnt/β-catenin pathway in the nucleus

被引：0
|
作者：
Wenxiao Han [1 ]
Hongying Wang [1 ]
机构：
[1] Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
来源：
Science Bulletin | 2014年 / 59卷 / 28期
关键词：
Regulation of canonical Wnt; catenin pathway in the nucleus;
D O I：
暂无
中图分类号：
R730.2 [肿瘤病理学、病因学];
学科分类号：
100214 ;
摘要：
Canonical Wnt/b-catenin pathway plays a central role in development, homeostasis, as well as tumorigenesis. The regulation of the pathway involves various and complicated mechanisms, including the extracellular, intracellular and endonuclear regulation. As the key component of the pathway, the Lef1/Tcfs-b-catenin complex is also the key target of regulation in the nucleus.In the current review, we are going to summarize the regulators in the nucleus which can modify the transcriptional activity of the Wnt/b-catenin pathway.
引用
收藏
页码：3530 / 3535
页数：6
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