Regulation of canonical Wnt/β-catenin pathway in the nucleus

被引：0
|
作者：
Wenxiao Han [1 ]
Hongying Wang [1 ]
机构：
[1] Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
来源：
Science Bulletin | 2014年 / 59卷 / 28期
关键词：
Regulation of canonical Wnt; catenin pathway in the nucleus;
D O I：
暂无
中图分类号：
R730.2 [肿瘤病理学、病因学];
学科分类号：
100214 ;
摘要：
Canonical Wnt/b-catenin pathway plays a central role in development, homeostasis, as well as tumorigenesis. The regulation of the pathway involves various and complicated mechanisms, including the extracellular, intracellular and endonuclear regulation. As the key component of the pathway, the Lef1/Tcfs-b-catenin complex is also the key target of regulation in the nucleus.In the current review, we are going to summarize the regulators in the nucleus which can modify the transcriptional activity of the Wnt/b-catenin pathway.
引用
收藏
页码：3530 / 3535
页数：6
相关论文
共 50 条
  • [1] Regulation of canonical Wnt/β-catenin pathway in the nucleus
    Han, Wenxiao
    Wang, Hongying
    CHINESE SCIENCE BULLETIN, 2014, 59 (28): : 3530 - 3535
  • [2] Arterial Stiffness and the Canonical WNT/β-catenin Pathway
    Alexandre Vallée
    Current Hypertension Reports, 2022, 24 : 499 - 507
  • [3] Reconstituting regulation of the canonical Wnt pathway by engineering a minimal β-catenin destruction machine
    Pronobis, Mira I.
    Deuitch, Natalie
    Posham, Vinya
    Mimori-Kiyosue, Yuko
    Peifer, Mark
    MOLECULAR BIOLOGY OF THE CELL, 2017, 28 (01) : 41 - 53
  • [4] Cannabidiol and the Canonical WNT/β-Catenin Pathway in Glaucoma
    Vallee, Alexandre
    Lecarpentier, Yves
    Vallee, Jean-Noel
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (07)
  • [5] Arterial Stiffness and the Canonical WNT/β-catenin Pathway
    Vallee, Alexandre
    CURRENT HYPERTENSION REPORTS, 2022, 24 (11) : 499 - 507
  • [6] HAT cofactor TRRAP mediates β-catenin ubiquitination on the chromatin and the regulation of the canonical Wnt pathway
    Finkbeiner, Martin G.
    Sawan, Carla
    Ouzounova, Maria
    Murr, Rabih
    Herceg, Zdenko
    CELL CYCLE, 2008, 7 (24) : 3908 - 3914
  • [7] Regulation of β-catenin signaling in the Wnt pathway
    Kikuchi, A
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 268 (02) : 243 - 248
  • [8] Targeting the canonical Wnt/-catenin pathway in hematological malignancies
    Ashihara, Eishi
    Takada, Tetsuya
    Maekawa, Taira
    CANCER SCIENCE, 2015, 106 (06) : 665 - 671
  • [9] Regulation of the canonical Wnt pathway by endocytic proteins
    Torun, A.
    Rashid, S.
    Szymanska, E.
    Pilecka, I.
    Miaczynska, M.
    FEBS JOURNAL, 2011, 278 : 482 - 482
  • [10] Regulation of the Wnt/β-catenin pathway by redox signaling
    Korswagen, HC
    DEVELOPMENTAL CELL, 2006, 10 (06) : 687 - 688
12345