The influence of dihydropyridines calcium antagonists on 5-HT-induced intracellular calcium signal

被引：0
|
作者：
WANG ShuMin1
2 Beijing Tongren Hospital
3 Chinese PLA General Hospital
4 Chinese PLA General Hospital of Rocket Forces
机构：
来源：
Science China Chemistry | 2007年 / 04期
关键词：
lacidipine; calcium sparks; stomach fundus smooth muscle cells; confocal laser scanning microscopy;
D O I：
暂无
中图分类号：
O621.2 [有机化合物性质];
学科分类号：
070303 ; 081704 ;
摘要：
Confocal laser scanning microscopy (CLSM) was applied to detect the intracellular [Ca2+] variety of fluorescent intension, with Fluo-3/AM fluorescence loaded in SFSMC. The results show that 10 μmol/L Lacidipine can reduce the frequence which 10 μmol/L 5-HT induced [Ca2+] spark in SFSMC of calcium over loading to 50%, and amplitude to 50% or so. We can draw a conclusion that dihydropyridines cal-cium antagonists lacidipine can antagonize the release of intracellular [Ca2+] which 5-HT-induced in dose dependent manner.
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页码：562 / 567
页数：6
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