Quinine-derived thiourea promoted enantioselective Michael addition reactions of 3-substituted phthalides to maleimides

被引：0

作者：

Jie Wang ^{[1
]}

Xin Li ^{[1
]}

Jin-Pei Cheng ^{[1
]}

机构：

[1] State Key Laboratory of Elemento-Organic Chemistry,Collaborative Innovation Center of Chemical Science and Engineering,College of Chemistry,Nankai University

来源：

Science China(Chemistry) | 2019年 / 05期

基金：

中国国家自然科学基金;

关键词：

michael addition; 3,3′-disubstituted phthalides; vicinal quaternary-tertiary stereogenic centers;

D O I：

暂无

中图分类号：

O621.25 [];

学科分类号：

摘要：

A highly diastereoselective and enantioselective Michael addition/desymmetrization reaction of maleimides with prochiral 3-substituted phthalides catalyzed by quinine-derived bifunctional thiourea was realized. A broad range of the 3,3′-disubstituted phthalides bearing vicinal quaternary-tertiary stereogenic centers were synthesized in moderate to good yields(up to 96%) with high diastereoselectivities(up to >19:1 dr) and enantioselectivities(up to 96:4 er).

引用

页码：649 / 652

页数：4

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