Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys

被引：0

作者：

Jin Yang ^{[1
,2
]}

Yaqi An ^{[1
,2
]}

Haiyan Wu ^{[1
,2
]}

Miao Liu ^{[1
,2
]}

Weiguang Wang ^{[1
]}

Xue Du ^{[1
]}

Yan Li ^{[1
]}

Jianxin Pu ^{[1
]}

Handong Sun ^{[1
]}

机构：

[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences

[2] University of Chinese Academy of Sciences

来源：

Science China Chemistry | 2016年 / 09期

基金：

中国国家自然科学基金; 中国科学院西部之光基金;

关键词：

Isodon phyllostachys; diterpenoid; ent-kaurane; ent-abietane;

D O I：

暂无

中图分类号：

O629 [天然化合物]; TQ460.1 [基础理论];

学科分类号：

070303 ; 081704 ; 1007 ;

摘要：

Four new diterpenoids, phyllostachysins I–L(1–4), along with a known one, hebeiabinin B(5), were isolated from the aerial parts of Isodon phyllostachys(I. phyllostachys). Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated by means of spectroscopic analysis. Compounds 3 and 4 exhibited significant cytotoxic activity against human tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and strongly inhibited NO production in LPS-stimulated RAW264.7 cells.

引用

页码：1211 / 1215

页数：5

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