Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma

被引：0
|
作者：
WANG GuiLan1 & LU JiRong2* 1Department of Pediatrics
2Department of Pediatrics
机构：
来源：
Science China Life Sciences | 2010年 / 10期
关键词：
asthma model; retrovirus vector; IL-4RA; gene transfer;
D O I：
暂无
中图分类号：
R562.25 [];
学科分类号：
1002 ; 100201 ;
摘要：
This work reports the investigation of the effect of airway IL-4RA gene transfer by a recombinant retroviral vector on airway inflammation and airway responsiveness in asthmatic mice. The retrovirus-mediated delivery of IL-4RA to the airways of mice inhibited elevations of airway responsiveness and the development of allergic inflammation in asthmatic mice, and regulated the Th1/Th2 balance in OVA-sensitized and -challenged mouse models. This suggests that gene therapy is a therapeutic option for treating and controlling chronic airway inflammation and asthma symptoms.
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页码：1215 / 1220
页数：6
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