Hyposmia: a possible biomarker of Parkinson's disease

被引：8
|
作者：
Qian Xiao [1 ]
Sheng Chen [1 ]
Weidong Le [1 ,2 ]
机构：
[1] Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
[2] Institutes of Translational Medicine, 1st Affiliated Hospital of Dalian Medical Universtiy
来源：
Neuroscience Bulletin | 2014年 / 30卷 / 01期
基金：
中国国家自然科学基金;
关键词：
hyposmia; Parkinson’s disease; olfaction; biomarker;
D O I：
暂无
中图分类号：
R742.5 [震颤麻痹综合征];
学科分类号：
1002 ;
摘要：
Hyposmia, identified as reduced sensitivity to odor, is a common non-motor symptom of Parkinson’s disease (PD) that antedates the typical motor symptoms by several years. It occurs in ~90% of early-stage cases of PD. In addition to the high prevalence, the occurrence of hyposmia may also predict a higher risk of PD. Investigations into hyposmia and its relationship with PD may help elucidate the underlying pathogenic mechanisms. This review provides an update of olfactory dysfunction in PD and its potential as a biomarker for this devastating disease.
引用
收藏
页码：134 / 140
页数：7
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