Mechanisms of chromatin-based epigenetic inheritance

被引：2

作者：

Wenlong Du ^{[1
]}

Guojun Shi ^{[2
]}

Chun-Min Shan ^{[3
]}

Zhiming Li ^{[4
]}

Bing Zhu ^{[1
,5
]}

Songtao Jia ^{[6
]}

Qing Li ^{[2
]}

Zhiguo Zhang ^{[4
]}

机构：

[1] National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

[2] State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences and Peking-Tsinghua Center for Life Sciences,Peking University

[3] State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences

[4] Institutes of Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center

[5] College of Life Sciences, University of Chinese Academy of Sciences

[6] Department of Biological Sciences, Columbia University

来源：

Science China(Life Sciences) | 2022年 / 11期

基金：

中国国家自然科学基金; 中国博士后科学基金; 美国国家卫生研究院;

关键词：

D O I：

暂无

中图分类号：

Q343.2 [染色体理论（染色体遗传学）];

学科分类号：

摘要：

Multi-cellular organisms such as humans contain hundreds of cell types that share the same genetic information(DNA sequences), and yet have different cellular traits and functions. While how genetic information is passed through generations has been extensively characterized, it remains largely obscure how epigenetic information encoded by chromatin regulates the passage of certain traits, gene expression states and cell identity during mitotic cell divisions, and even through meiosis. In this review, we will summarize the recent advances on molecular mechanisms of epigenetic inheritance, discuss the potential impacts of epigenetic inheritance during normal development and in some disease conditions, and outline future research directions for this challenging, but exciting field.

引用

页码：2162 / 2190

页数：29

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