Isolation, identification, and cytotoxicity of a new isobenzofuran derivative from marine Streptomyces sp. W007

被引：0
|
作者：
张宏宇 [1 ]
谢则平 [2 ]
娄婷婷 [3 ]
姜鹏 [4 ]
机构：
[1] Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce
[2] School of Pharmacy, Binzhou Medical University
[3] Tianjin Entry & Exit Inspection and Quarantine Bureau
[4] Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
来源：
Journal of Oceanology and Limnology | 2016年 / 02期
关键词：
marine streptomycete; isobenzofuran derivative; absolute configuration; cytotoxicity;
D O I：
暂无
中图分类号：
R961 [药物的性质和作用];
学科分类号：
100602 ; 100706 ;
摘要：
A new isobenzofuran derivative( 1) was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyses, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute configuration of compound 1 was determined by a combination of experimental analyses and comparison with reported data, including biogenetic reasoning, J-coupling analysis, NOESY, and 1 H- 1 HCOSY. Compound 1 exhibited no cytotoxicity against human cells of gastric cancer BGC-823, lung cancer A549, and breast cancer MCF7.
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页码：386 / 390
页数：5
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