Orthotopic liver transplantation with hepatopancreatoduodenectomy for hilar cholangiocarcinoma

Although the surgical treatment for hilarcholangiocarcinoma represents the only potentiallycurative option, local excision and major hepatectomyhave failed to produce a favorable survival figure over thelast decade. This is partly due to local tumor recurrenceswithin the resection margin, perineural sheaths infiltration,and the regional lymph nodes metastasis after the surgery.Recently, an extended bile duct resection combined withtotal hepatectomy, pancreatoduodenectomy, andorthotopic liver transplantation (HPLTx) was proposed toeradicate the entire biliary tract without cutting off thehepatoduodenal ligament. The results demonstrated an