Serum carbohydrate antigen-125 is elevated in patients with chronic atrial fibrillation

被引:1
|
作者
Pan Junqiang1
机构
关键词
Carbohydrate antigen-125; Chronic atrial fibrillation; Electrocardiograms; Sinus rhythm;
D O I
暂无
中图分类号
R541.75 [];
学科分类号
摘要
Objective: To determine whether CA-125 is elevated in medically stable patients with chronic atrial fibrillation (AF) compared with patients without AF and to examine whether levels of CA-125 are associated with demographic and clinical variables in a sample of patients under study. Methods: 55 patients with chronic AF and 58 control patients in sinus rhythm were included into the study. Patients with acute heart failure (HF), chronic inflammatory or neoplastic disease were excluded from the study. Circulating levels of CA-125 were assessed; all patients underwent clinical examination, assessment and medical records including demographic data, history of comorbid conditions, current use of cardiac medications, and the results of cardiac tests including electrocardiograms. Results: The mean age of the study sample was 53.2±6.5 years and 48% were men. Patients with sinus rhythm were significantly more likely to have lower heart rates, smaller dimensions of left atrium, and to be treated with aspirin. Coumadin, coumadin and digoxin were more often prescribed in patients with chronic AF. The CA-125 levels were significantly higher in patients with chronic AF than in patients in sinus rhythm (48.5±7.65 U/ml and 28.43±5.48 U/ml, P<0.005). An inverse relation was found between CA-125 levels and left ventricular ejection fraction (LVEF) (r=-0.48, P<0.001). CA-125 was significantly related to the left atrium (LA) diameter, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and brain natriuretic peptide (BNP). There was no significant correlation between CA-125 and age. Conclusion: In subjects with chronic AF, CA-125 levels are increased; CA-125 was significantly related to the LA diameter, LVEDD, LVESD and BNP.
引用
收藏
页码:286 / 293
页数:8
相关论文
共 50 条
  • [41] Correlation of Serum Cancer Antigen-125 (CA-125) Levels with Severity of Pre-eclampsia
    Bhatia, Pooja
    Goel, Poonam
    Mehra, Reeti
    Dubey, Sunita
    Gupta, Seema
    JOURNAL OF OBSTETRICS AND GYNECOLOGY OF INDIA, 2023, 73 (SUPPL 2): : 240 - 246
  • [42] Correlation of Serum Cancer Antigen-125 (CA-125) Levels with Severity of Pre-eclampsia
    Pooja Bhatia
    Poonam Goel
    Reeti Mehra
    Sunita Dubey
    Seema Gupta
    The Journal of Obstetrics and Gynecology of India, 2023, 73 : 240 - 246
  • [43] Measurement of serum levels of carbohydrate antigen 125 in patients with aortic valve stenosis
    Antonini-Canterin, F
    Popescu, AC
    Popescu, BA
    Rubin, D
    Cappelletti, P
    Piazza, R
    Cervesato, E
    Nicolosi, GL
    EUROPEAN HEART JOURNAL, 2004, 25 : 592 - 592
  • [44] Elevated lipoprotein(a) is a risk factor for left atrial thrombus in patients with chronic atrial fibrillation
    Yutaka, I
    Hiroshi, I
    Kenji, O
    Masayuki, Y
    Masahiro, I
    Yoshifusa, A
    CIRCULATION, 1997, 96 (08) : 731 - 731
  • [45] Addressing uncertainty regarding the utility of carbohydrate antigen-125 as a prognostic marker in non-Hodgkin lymphoma
    Ojha, Rohit P.
    Brown, Lindsey M.
    Felini, Martha J.
    Singh, Karan P.
    Thertulien, Raymond
    LEUKEMIA & LYMPHOMA, 2010, 51 (09) : 1754 - 1757
  • [46] Serum carbohydrate antigen 125 in patients with severe aortic stenosis and preserved ejection fraction
    Beladan, C. C.
    Calin, A.
    Popescu, B. A.
    Rosca, M.
    Muraru, D.
    Constantin, L.
    Dima, L.
    Antohi, L.
    Antonini-Canterin, F.
    Ginghina, C.
    EUROPEAN HEART JOURNAL, 2010, 31 : 127 - 127
  • [47] LUMINOIMMUNOMETRIC ASSAY OF TISSUE POLYPEPTIDE ANTIGEN (TPA) AND CANCER ANTIGEN-125 (CA-125) IN BREAST-CANCER PATIENTS
    ELAHMADY, O
    HALIM, AB
    EISSA, S
    DISEASE MARKERS, 1993, 11 (2-3) : 83 - 90
  • [48] Electrochemical immunoassay for based on polythionine and gold glassy carbon electrodes carbohydrate antigen-125 hollow microspheres modified
    Fu, Xiao-Hong
    ELECTROANALYSIS, 2007, 19 (17) : 1831 - 1839
  • [49] DETERMINATION OF TISSUE ANTIGEN-4 (TA-4) AND CANCER ANTIGEN-125 SERUM LEVELS IN PATIENTS WITH SQUAMOUS-CELL CARCINOMA
    SJOVALL, K
    KISS, B
    NORDSTROM, L
    JOHANNASSON, A
    STIBER, B
    SHOLDEFRIES, H
    ENEROTH, P
    LONSDORFER, M
    MULLER, P
    TUMOUR BIOLOGY, 1985, 6 (04): : 424 - 424
  • [50] A magneto-controlled microfluidic device for voltammetric immunoassay of carbohydrate antigen-125 with silver-polypyrrole nanotags
    Huang, Jiyi
    Huang, Chaoqun
    Zhong, Weimin
    Lin, Yao
    ANALYTICAL METHODS, 2020, 12 (34) : 4211 - 4219