Design,synthesis,in vitro evaluation of tetrahydropyrimidine-isatin hybrids as potential antibacterial,antifungal and anti-tubercular agents

被引：7

作者：

Tarunkumar Nanjibhai Akhaja ^{[1
]}

Jignesh Priyakant Raval ^{[1
]}

机构：

[1] Department of Pharmaceutical Chemistry,Ashok & Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences(ARIBAS),New Vallabh Vidyanagar-388121,Gujarat,India

来源：

ChineseChemicalLetters | 2012年 / 23卷 / 04期

关键词：

Tetrahydropyrimidines; Isatin; 1,3-Dihydro-2H-indol-2-ones; Biginelli reaction; CaCl2; catalyst; In vitro antituberculer activity; Antibacterial and antifungal activity;

D O I：

暂无

中图分类号：

TQ465 [抗菌素制造];

学科分类号：

100705 ;

摘要：

A series of 5-substitued-3-(5-(4-(furan-2-yl)-6-methyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2- ylimino)indolin-2-one derivatives were synthesized,characterized and were screened for anti-bacterial,anti-fungal and antitubercular activity.

引用

页码：446 / 449

页数：4

共 50 条

[21] Development and evaluation of new oxindole derivatives as potential anti-tubercular agents
Velavalapalli, Vani Madhuri
Kumar, G. Shiva
Katari, Naresh Kumar
Gundla, Rambabu
JOURNAL OF MOLECULAR STRUCTURE, 2024, 1304
[22] Synthesis and structure-activity relationships evaluation of benzothiazinone derivatives as potential anti-tubercular agents
Gao, Chao
Ye, Ting-Hong
Wang, Ning-Yu
Zeng, Xiu-Xiu
Zhang, Li-Dan
Xiong, Ying
You, Xin-Yu
Xia, Yong
Xu, Ying
Peng, Cui-Ting
Zuo, Wei-Qiong
Wei, Yuquan
Yu, Luo-Ting
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (17) : 4919 - 4922
[23] Synthesis and biological evaluation of dihydroquinoline carboxamide derivatives as anti-tubercular agents
Kumar, Gautam
Sathe, Asawari
Krishna, Vagolu Siva
Sriram, Dharmarajan
Jachak, Sanjay M.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 157 : 1 - 13
[24] Ciprofloxacin-isatin-1H-1,2,3-triazole Hybrids: Design, Synthesis, and in vitro Anti-tubercular Activity against M.tuberculosis
Xu, Zhi
Lv, Zao-Sheng
Song, Xu-Feng
Qiang, Min
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (01) : 97 - 102
[25] Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies
Hassan, Nayera W.
Saudi, Manal N.
Abdel-Ghany, Yasser S.
Ismail, Azza
Elzahhar, Perihan A.
Sriram, Dharmarajan
Nassra, Rasha
Abdel-Aziz, Marwa M.
El-Hawash, Soad A.
BIOORGANIC CHEMISTRY, 2020, 96
[26] Synthesis and in vitro evaluation of novel isatin-incorporated thiadiazole hybrids as potential anti-breast cancer agents
Kumar, Neeraj
Sharma, Chandra Shekhar
Singh, Hemendra Pratap
Chauhan, Lalit Singh
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2017, 16 (08) : 1957 - 1963
[27] Synthesis of coumarin-theophylline hybrids as a new class of anti-tubercular and anti-microbial agents
Mangasuli, Sumitra N.
Hosamani, Kallappa M.
Devarajegowda, Hirihalli C.
Kurjogi, Mahantesh M.
Joshi, Shrinivas D.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 146 : 747 - 756
[28] Discovery of New Isoniazid Derivatives As Anti-tubercular Agents: In silico Studies, Synthesis, and In vitro Activity Evaluation
Mohd, Abida Ash
Imran, Mohd
Alnaser, Noura Yousif
Altimyat, Shams Saud
Al-otaibi, Nawaf M.
Bawadekji, Abdulhakim
ORIENTAL JOURNAL OF CHEMISTRY, 2023, 39 (06) : 1510 - 1520
[29] Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents
Wang, Yan
Damu, Guri L. V.
Lv, Jing-Song
Geng, Rong-Xia
Yang, Da-Cheng
Zhou, Cheng-He
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (17) : 5363 - 5366
[30] Synthesis and biological evaluation of some novel isoxazoles and cyanopyridines, a new class of potential anti-tubercular agents
Doshi, R
Kagthara, P
Parekh, H
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1999, 38 (03): : 348 - 352

← 1 2 3 4 5 →