Development of nanocrystal formulation of mebendazole with improved dissolution and pharmacokinetic behaviors

被引：0
|
作者：
Naofumi Hashimoto [1 ]
Kayo Yuminoki [1 ]
Haruka Takeuchi [1 ]
Chiaki Okada [1 ]
机构：
[1] Setsunan University
来源：
AsianJournalofPharmaceuticalSciences | 2016年 / 11卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R943 [制剂学];
学科分类号：
100602 ; 100702 ;
摘要：
Nanosizing by wet beads milling is a method to improve the solubility of poorly water soluble compounds [1,2]. Mebendazole(MBZ) is a well-known anthelmintic drug in wide clinical use.There were some reports that MBZ had the anticancer effect in preclinical study. However, the bioavailability of MEB is low(<10%) due to the poor solubility in water (0.5μg/mL). The present study aimed to develop the nanocrystal formula-
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页码：122 / 123
页数：2
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