Hypoglycemic Effects of Different Solvent Extracts from FRUCTUS PHYLLANTHI

[Objective]To investigate the hypoglycemic effects of different solvent extracts from FRUCTUS PHYLLANTHI. [Method]After the water extraction,FRUCTUS PHYLLANTHI was concentrated into extracts; water was added in order to prepare the solution. Then,ethyl ether,ethyl acetate,and n-butanol were used to obtain the ethyl ether extracts,ethyl acetate extracts,n-butanol extracts,and water soluble extracts,respectively. Taking diabetic mice induced by STZ as the model,hypoglycemic effects of different solvent extracts from FRUCTUS PHYLLANTHI were studied with blood glucose,body weight,spleen index,and thymus index as the indices. [Result]Compared the DG with the four extracts groups,mice in Ph-B showed the most significant hypoglycemic effects,the reduction of mice body weight was restricted and the spleen index was enhanced. [Conclusion]Ethyl acetate extracts from FRUCTUS PHYLLANTHI could significantly reduce the hyperglycemia caused by STZ.