Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk

被引：0
|
作者：
Mansour S Al-Moundhri [1 ]
Manal Al-Khanbashi [2 ]
Mohammed Al-Kindi [3 ]
Maryam Al-Nabhani [2 ]
Ikram A Burney [1 ]
Abdulaziz Al-Farsi [4 ]
Bassim Al-Bahrani [4 ]
机构：
[1] Medical Oncology Unit,Department of Medicine,College of Medicine and Health Sciences,Sultan Qaboos University
[2] Department of Clinical Genetics,College of Medicine and Health Sciences,Sultan Qaboos University
[3] Department of Biochemistry,College of Medicine and Health Sciences,Sultan Qaboos University
[4] National Oncology Center,Royal Hospital
来源：
World Journal of Gastroenterology | 2010年 / 16卷 / 27期
关键词：
Gastric cancer; Polymorphism; CDH1;
D O I：
暂无
中图分类号：
R735.2 [胃肿瘤];
学科分类号：
100214 ;
摘要：
AIM:To investigate the associations between CDH1 gene polymorphisms and gastric cancer(GC) risk predisposition.METHODS:We analyzed four CDH1 polymorphisms(+54 T>C,-160 C>A,-616 G>C,-3159 T>C) in an Omani population,by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing.RESULTS:CDH1-160-AA genotype was associated with an increased risk of GC(OR = 3.6,95% CI:1.1-11.8)(P = 0.03).There was no significant association between the other polymorphisms and GC risk.The haplotype analysis of +54 T>C,-160 C>A,-616 G>C,-3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5(95% CI:0.7-3.5) and 1.5(95% CI:0.2-3.0),but did not reach statistical significance.CONCLUSION:The current study suggests that the-160 AA genotype was associated with an increased risk of GC in Oman.
引用
收藏
页码：3432 / 3436
页数：5
相关论文
共 50 条
  • [1] Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk
    Al-Moundhri, Mansour S.
    Al-Khanbashi, Manal
    Al-Kindi, Mohammed
    Al-Nabhani, Maryam
    Burney, Ikram A.
    Al-Farsi, Abdulaziz
    Al-Bahrani, Bassim
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (27) : 3432 - 3436
  • [2] Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer
    Kiemeney, Lambertus A.
    van Houwelingen, Kjeld P.
    Bogaerts, Manon
    Witjes, J. Alfred
    Swinkels, Dorine W.
    den Heijer, Martin
    Franke, Barbara
    Schalken, Jack A.
    Verhaegh, Gerald W.
    [J]. EUROPEAN JOURNAL OF CANCER, 2006, 42 (18) : 3219 - 3227
  • [3] Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer
    Kiemeney, L. A. L. M.
    Van Houwelingen, K. P.
    Bogaerts, M.
    Witjes, J. A.
    Swinkels, D. W.
    Den Heijer, M.
    Franke, B.
    Schalken, J. A.
    Verhaegh, G. W.
    [J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2006, 21 : 90 - 90
  • [4] Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer
    Kiemeney, LA
    Van Houwelingen, KP
    Bogaerts, M
    Witjes, JA
    Swinkels, DW
    Den Heijer, M
    Franke, B
    Schalken, JA
    Verhaegh, GW
    [J]. JOURNAL OF UROLOGY, 2006, 175 (04): : 198 - 198
  • [5] Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer.
    Kiemeney, L.
    van Houwelingen, K.
    Bogaerts, M.
    Witjes, A.
    Swinkels, D.
    den Heijer, M.
    Franke, B.
    Schalken, J.
    Verhaegh, G.
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2006, 163 (11) : S110 - S110
  • [6] Association between E-cadherin (CDH1) polymorphisms and pancreatic cancer risk in Han Chinese population
    Zhao, Lei
    Wang, Ying-Xue
    Xi, Mian
    Liu, Shi-Liang
    Zhang, Peng
    Luo, Li-Ling
    Liu, Meng-Zhong
    [J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (05): : 5753 - 5760
  • [7] Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer
    Chien, Ming-Hsien
    Chou, Lin Shih-Shen
    Chung, Tsung-Te
    Lin, Chien-Huang
    Chou, Ming-Yung
    Weng, Meng-Shih
    Yang, Shun-Fa
    Chen, Mu-Kuan
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2012, 34 (03): : 405 - 411
  • [8] E-cadherin (CDH1) gene promoter polymorphism and the risk of colorectal cancer
    Wang, Yadong
    Yang, Haiyan
    Li, Li
    Wang, Haiyu
    Zhang, Congke
    Xia, Xiangqun
    [J]. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2012, 27 (02) : 151 - 158
  • [9] Gene of the month: E-cadherin (CDH1)
    Gall, Tamara M. H.
    Frampton, Adam E.
    [J]. JOURNAL OF CLINICAL PATHOLOGY, 2013, 66 (11) : 928 - 932
  • [10] E-Cadherin (CDH1 Gene) Germline Mutations in Gastric Cancer: Evolutions and Innovations
    Corso, Giovanni
    Bonanni, Bernardo
    [J]. CANCERS, 2020, 12 (10)
12345