FunMod: A Cytoscape Plugin for Identifying Functional Modules in Undirected Protein–Protein Networks

被引：0

作者：

Massimo Natale ^{[1
]}

Alfredo Benso ^{[1
]}

Stefano Di Carlo ^{[1
]}

Elisa Ficarra ^{[1
]}

机构：

[1] Department of Control and Computer Engineering, Politecnico di Torino

来源：

Genomics,Proteomics & Bioinformatics | 2014年 / 04期

关键词：

Systems biology; Network analysis; Pathway analysis; Network modules; Cytoscape; Budd–Chiari syndrome;

D O I：

暂无

中图分类号：

Q811.4 [生物信息论];

学科分类号：

0711 ; 0831 ;

摘要：

The characterization of the interacting behaviors of complex biological systems is a primary objective in protein–protein network analysis and computational biology. In this paper we present FunMod, an innovative Cytoscape version 2.8 plugin that is able to mine undirected protein–protein networks and to infer sub-networks of interacting proteins intimately correlated with relevant biological pathways. This plugin may enable the discovery of new pathways involved in diseases. In order to describe the role of each protein within the relevant biological pathways, FunMod computes and scores three topological features of the identified sub-networks. By integrating the results from biological pathway clustering and topological network analysis, FunMod proved to be useful for the data interpretation and the generation of new hypotheses in two case studies.

引用

页码：178 / 186

页数：9

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