Transcription factor PDX-1 in human colorectal adenocarcinoma:A potential tumor marker?

被引：2
|
作者：
Nikiforos Ballian [1 ]
Francis Charles Brunicardi [1 ]
机构：
[1] the Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden, Suite 1500 Houston,TX 77030, United States
来源：
World Journal of Gastroenterology | 2008年 / 38期
关键词：
Colorectal cancer; Pancreatic duodenal homeobox-1; Tumor marker; Transcription factor; Diagnostics;
D O I：
暂无
中图分类号：
R735.3 [肠肿瘤];
学科分类号：
100214 ;
摘要：
AIM: To examine the expression of pancreatic duodenal homeobox-1 (PDX-1) transcription factor in human colorectal cancer. METHODS: RT-PCR, Western blotting, and immuno-histochemistry were performed to determine the expression pattern of transcription factor PDX-1 in primary colorectal tumor, hepatic metastasis, and benign colon tissue from a single patient. RESULTS: The highest PDX-1 transcription levels were detected in the metastasis material. Lower levels of PDX-1 were found to be present in the primary tumor, while normal colon tissue failed to express detectable levels of PDX-1. Western blot data revealed a PDX-1 expression pattern identical to that of mRNA expression. Immunohistochemistry confirmed high metastasis PDX-1 expression, lower levels in the primary tumor, and the presence of only traces of PDX-1 in normal colon tissue. CONCLUSION: These data argue for further evaluation of PDX-1 as a biomarker for colorectal cancer.
引用
收藏
页码：5823 / 5826
页数：4
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