Numerical simulation of inhibiting effects on solid tumour cells in anti-angiogenic therapy: application of coupled mathematical model of angiogenesis with tumour growth

被引：5
|
作者：
蔡彦 [1 ]
吴洁 [2 ]
许世雄 [1 ]
龙泉 [3 ]
姚伟 [1 ]
机构：
[1] Department of Mechanics and Engineering Science, Fudan University
[2] School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University
[3] Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
来源：
Applied Mathematics and Mechanics(English Edition) | 2011年 / 32卷 / 10期
基金：
中国国家自然科学基金;
关键词：
tumour angiogenesis; tumour growth; anti-angiogenic therapy; coupled mathematical model;
D O I：
暂无
中图分类号：
R730.2 [肿瘤病理学、病因学];
学科分类号：
100214 ;
摘要：
To investigate the inhibiting effects of the anti-angiogenic factor andostatin and the anti-angiogenic drug endostatin on tumour angiogenesis and tumour cells, a coupled mathematical model of tumor angiogenesis with tumour growth and blood perfusion is developed. Simulation results show that angiostatin and endostatin can improve the abnormal microenvironment inside the tumour tissue by effectively inhibiting the process of tumor angiogenesis and decreasing tumour cells. The present model can be used as a valid theoretical method in the investigation of the tumour anti-angiogenic therapy.
引用
收藏
页码：1287 / 1296
页数：10
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