This article is concerned with the oscillation of the forced second order differential equation with mixed nonlinearities a(t) x ′ (t) γ′ + p 0 (t) x γ (g 0 (t)) + n i =1 p i (t) | x (g i (t)) | α i sgn x (g i (t)) = e(t), where γ is a quotient of odd positive integers, α i > 0, i = 1, 2, ··· , n, a, e, and p i ∈ C ([0, ∞ ) , R), a (t) > 0, gi : R → R are positive continuous functions on R with lim t →∞ g i (t) = ∞ , i = 0, 1, ··· , n. Our results generalize and improve the results in a recent article by Sun and Wong [29].