Study of ionizable drugs transfer across the water/1,2-dichloroethane interface with phase volume ratio equal to unity using a three-electrode system

被引：0

作者：

ZHANG Meiqin1

2. College of Chemistry and Molecular Engineering

机构：

来源：

Science Bulletin | 2003年 / 12期

关键词：

water/1; 2-dichloroethane interface; ionizable drug trans-fer; three-electrode system; phase volume ratio; ionic partition dia-gram;

D O I：

暂无

中图分类号：

TQ460 [一般性问题];

学科分类号：

1007 ;

摘要：

The electrochemical behavior of ionizable drugs (Amitriptyline, Diphenhydramine and Trihexyphene- dyl) at the water/1,2-dichloroethane interface with the phase volume ratio (r = Vo/Vw) equal to 1 are investigated by cyclic voltammetry. The system is composed of an aqueous droplet supported at an Ag/AgCl disk electrode and it was covered with an organic solution. In this manner, a conventional three-electrode potentiostat can be used to study the ioni-zable drugs transfer process at a liquid/liquid interface. Physicochemical parameters such as the formal transfer potential, the Gibbs energy of transfer and the standard par-tition coefficients of the ionized forms of these drugs can be evaluated from cyclic voltammograms obtained. The ob-tained results have been summarized in ionic partition dia-grams, which are a useful tool for predicting and interpret-ing the transfer mechanisms of ionizable drugs at the liq-uid/liquid interfaces and biological membranes.

引用

页码：1234 / 1239

页数：6

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