Effect of antiarrhythmic drug E-4031 on Na~+/Ca2+ exchange currents in isolated guinea pig ventricular myocytes

被引：2

作者：

武冬梅

吕吉元

边竹平

顿文

吴博威

机构：

[1] 山西医科大学生理学教研室

[2] 大同市第二卫生学校

来源：

中国药理学与毒理学杂志 | 1999年 / 03期

关键词：

抗心律失常药; E－4031; 膜片钳技术; 心肌; 离子交换;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

应用全细胞电压钳的斜坡脉冲程序测定离体豚鼠心肌细胞准稳态电流电压关系曲线，研究Ⅲ类抗心律失常药Ｅ－４０３１对Ｎａ＋／Ｃａ２＋交换电流的影响，结果表明Ｅ－４０３１０．１，１．０，１０，５０μｍｏｌ·Ｌ－１使Ｎｉ２＋敏感电流浓度依赖性增加，膜电位＋５０ｍＶ时分别增加（７０±３８）％，（９１±５３）％，（１１８±６３）％，（１２２±５１）％；膜电位－１００ｍＶ时增加（２５±２０）％，（５１±３２）％，（１１３±８４）％，（９３±７３）％。提示Ｅ－４０３１对心室肌细胞Ｎａ＋／Ｃａ２＋交换电流的增强作用可能是其正性变力作用的重要机理。

引用

页码：26 / 29

页数：4

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