Seroprevalence of HCV and its co-infection with HBV and HIV among liver disease patients of South Tamil Nadu
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作者:
Ganesh Kumar Anbazhagan
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Thirunalasundari Thiyagarajan 620024,Tamil Nadu,India
National Facility for Marine Cyanobacteria,Bharathidasan UniversityThirunalasundari Thiyagarajan 620024,Tamil Nadu,India
Ganesh Kumar Anbazhagan
[1
,2
]
Sridharan Krishnamoorthy
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机构:
Thirunalasundari Thiyagarajan 620024,Tamil Nadu,India
Department of Gastroenterology,KAP Viswanatham Government Medical College and Annal Gandhi Memorial Government HospitalThirunalasundari Thiyagarajan 620024,Tamil Nadu,India
Hepatitis C virus;
Hepatitis B virus;
Human immunodeficiency virus;
Co-infection;
Liver function test;
D O I:
暂无
中图分类号:
R512.6 [病毒性肝炎];
R512.91 [获得性免疫缺陷综合征(AIDS艾滋病)];
学科分类号:
100401 ;
摘要:
AIM:To determine the seroprevalence of hepatitis C virus(HCV) and its co-infection with hepatitis B virus(HBV),hepatitis delta agent(HDV) and human immunodeficiency virus(HIV) among liver disease patients of south Tamil Nadu. METHODS:A total of 1012 samples comprising 512 clinically diagnosed cases of liver disease patients and 500 apparently healthy age and sex matched individuals were screened for Hepatitis C virus(anti HCV and HCV RNA) ,Hepatitis B virus(HBsAg),Hepatitis delta agent(anti HDV) and Human immuno virus(antibodies to HIV-1 and HIV-2) using commercially available enzyme linked immunosorbent assay kits.HCV RNA wasdetected by RT-PCR.Liver function tests like ALT,AST,GGT,ALP,bilirubin and albumin were also studied. RESULTS:The seroprevalence of HCV was found to be 5.6%among liver disease patients by ELISA.27/512,49/512 and 12/512 patients were positive for HIV,HBV &HDV respectively.Co-infection of HCV&HBV was found in 8 patients,with 6 for HCV&HIV and 4 for HCV,HBV&HIV co-infections.Sex-wise analysis showed that HIV,HCV&HBV and HCV&HIV co-infection was high among females whereas for HBV it was high in males. The mean ALT and AST in HCV positive cases were 42.1±8.3 and 49±10.1.In people co-infected with HCV&HBV or HCV&HIV or HCV,HBV&HIV the mean ALT of 58.0±03.16,56.78±4.401 and 64.37±4.01 respectively. CONCLUSION:We strongly recommend routine test of the blood for HCV in addition to HBV and HIV.We also recommend individualized counseling to identify those at risk and testing for those who want it.Improved surveillance and periodic epidemiological studies will have to be undertaken to monitor and prevent these blood-borne viruses.
机构:
China Med Univ, Hosp 1, Minist Hlth, Key Lab AIDS Immunol, Shenyang, Liaoning, Peoples R China
Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Beijing, Peoples R ChinaChina Med Univ, Hosp 1, Minist Hlth, Key Lab AIDS Immunol, Shenyang, Liaoning, Peoples R China
Zhang, Fujie
Zhou, Shuntai
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Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Beijing, Peoples R ChinaChina Med Univ, Hosp 1, Minist Hlth, Key Lab AIDS Immunol, Shenyang, Liaoning, Peoples R China
Zhou, Shuntai
Chen, Xi
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Hunan Ctr Dis Control & Prevent, Changsha, Hunan, Peoples R ChinaChina Med Univ, Hosp 1, Minist Hlth, Key Lab AIDS Immunol, Shenyang, Liaoning, Peoples R China
Chen, Xi
Ji, Guoping
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Anhui Ctr Dis Control & Prevent, Hefei, Peoples R ChinaChina Med Univ, Hosp 1, Minist Hlth, Key Lab AIDS Immunol, Shenyang, Liaoning, Peoples R China
Ji, Guoping
Lu, Ying
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Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Beijing, Peoples R ChinaChina Med Univ, Hosp 1, Minist Hlth, Key Lab AIDS Immunol, Shenyang, Liaoning, Peoples R China
Lu, Ying
Wu, Yasong
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Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Beijing, Peoples R ChinaChina Med Univ, Hosp 1, Minist Hlth, Key Lab AIDS Immunol, Shenyang, Liaoning, Peoples R China
Wu, Yasong
Liu, Zhongfu
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Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Beijing, Peoples R ChinaChina Med Univ, Hosp 1, Minist Hlth, Key Lab AIDS Immunol, Shenyang, Liaoning, Peoples R China
Liu, Zhongfu
Shang, Hong
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China Med Univ, Hosp 1, Minist Hlth, Key Lab AIDS Immunol, Shenyang, Liaoning, Peoples R ChinaChina Med Univ, Hosp 1, Minist Hlth, Key Lab AIDS Immunol, Shenyang, Liaoning, Peoples R China
机构:
Bakirkoy Dr Sadi Konuk Training & Res Hosp, Infect Dis & Clin Microbiol, TR-34147 Istanbul, TurkeyBakirkoy Dr Sadi Konuk Training & Res Hosp, Infect Dis & Clin Microbiol, TR-34147 Istanbul, Turkey
Senoglu, Sevtap
Yesilbag, Zuhal
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Bakirkoy Dr Sadi Konuk Training & Res Hosp, Infect Dis & Clin Microbiol, TR-34147 Istanbul, TurkeyBakirkoy Dr Sadi Konuk Training & Res Hosp, Infect Dis & Clin Microbiol, TR-34147 Istanbul, Turkey
Yesilbag, Zuhal
Karaosmanoglu, Hayat Kumbasar
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Bakirkoy Dr Sadi Konuk Training & Res Hosp, Infect Dis & Clin Microbiol, TR-34147 Istanbul, TurkeyBakirkoy Dr Sadi Konuk Training & Res Hosp, Infect Dis & Clin Microbiol, TR-34147 Istanbul, Turkey
Karaosmanoglu, Hayat Kumbasar
Aydin, Ozlem Altuntas
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Bakirkoy Dr Sadi Konuk Training & Res Hosp, Infect Dis & Clin Microbiol, TR-34147 Istanbul, TurkeyBakirkoy Dr Sadi Konuk Training & Res Hosp, Infect Dis & Clin Microbiol, TR-34147 Istanbul, Turkey
机构:
Jahrom Univ Med Sci, Zoonoses Res Ctr, Jahrom, Iran
Jahrom Univ Med Sci, Student Res Comm, Jahrom, IranJahrom Univ Med Sci, Zoonoses Res Ctr, Jahrom, Iran
Bazmjoo, Ahmadreza
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Bagherzadeh, Mohammad Aref
Raoofi, Rahim
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Jahrom Univ Med Sci, Zoonoses Res Ctr, Jahrom, Iran
Jahrom Univ Med Sci, Dept Infect Dis, Jahrom, IranJahrom Univ Med Sci, Zoonoses Res Ctr, Jahrom, Iran
Raoofi, Rahim
Taghipour, Ali
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Jahrom Univ Med Sci, Zoonoses Res Ctr, Jahrom, Iran
Jahrom Univ Med Sci, Dept Parasitol & Mycol, Jahrom, IranJahrom Univ Med Sci, Zoonoses Res Ctr, Jahrom, Iran
Taghipour, Ali
Mazaherifar, Samaneh
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Jahrom Univ Med Sci, Zoonoses Res Ctr, Jahrom, Iran
Jahrom Univ Med Sci, Dept Parasitol & Mycol, Jahrom, IranJahrom Univ Med Sci, Zoonoses Res Ctr, Jahrom, Iran
Mazaherifar, Samaneh
Sotoodeh, Hojatallah
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Fasa Univ Med Sci, Dept Dis Control, Fasa, IranJahrom Univ Med Sci, Zoonoses Res Ctr, Jahrom, Iran
Sotoodeh, Hojatallah
Ostadi, Zahra
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机构:Jahrom Univ Med Sci, Zoonoses Res Ctr, Jahrom, Iran
Ostadi, Zahra
Shadmand, Enayat
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Jahrom Univ Med Sci, Zoonoses Res Ctr, Jahrom, Iran
Jahrom Univ Med Sci, Dept Parasitol & Mycol, Jahrom, IranJahrom Univ Med Sci, Zoonoses Res Ctr, Jahrom, Iran