Effects of heparin on liver fibrosis in patients with chronic hepatitis B

AIM:To evaluate the effects of heparin on liver fibrosis inpatients with chronic hepatitis B.METHODS:Fifty-two cases under study were divided intotwo groups,group A and group B.The two groups weregiven regular treatment and heparin/low molecular weightheparin (LMWH) treatment respectively.Hepatic functions,serum hyaluronic acid (HA) and type IV collagen levels weremeasured before and after the treatment,and six caseswere taken liver biopsy twice.RESULTS:After treatment,hepatic functions becamesignificantly better in both groups.Serum HA and type IVcollagen levels in group B compared with group A,decreasedsignificantly after treatment.Collagen proliferation alsodecreased in group B after treatment.CONCLUSION:Heparin/LMWH can inhibit collagenproliferation in liver tissues with hepatitis B.