Overexpression of sterol carrier protein-2 mRNA in patients with cholesterol gallstones

被引：3
|
作者：
Nai-Qiang Cui
机构：
来源：
Hepatobiliary&PancreaticDiseasesInternational | 2005年 / 01期
关键词：
SCP2 mRNA expression; lithogenic biles; cholesterol gallstone;
D O I：
暂无
中图分类号：
R575.6 [胆囊疾病];
学科分类号：
摘要：
BACKGROUND: Hypersecretion of biliary cholesterol is believed to be one of the important causes of lithogenic bile. Sterol carrier protein-2 ( SCP2 ) participates in choles- terol trafficking and metabolism and may play a key role in cholesterol gallstone formation. This study was undertaken to investigate the expression of liver SCP2 mRNA in pa- tients with cholesterol gallstone and those patients with non-cholesterol gallstone. METHODS: The expression of liver SCP2 mRNA was studi- ed in 36 patients with cholesterol gallstone and 30 patients with non-cholesterol gallstone by reverse transcription-poly- merase chain reaction (RT-PCR). RESULT: The expression of SCP2 mRNA was increased more significantly in patients with cholesterol gallstone than in patients with non-cholesterol gallstone. CONCLUSION: The SCP2 gene was overexpressed in pa- tients with cholesterol gallstone, indicating that SCP2 may be one of the important causes of cholesterol gallstone.
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收藏
页码：117 / 120
页数：4
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