Overexpression of sterol carrier protein-2 mRNA in patients with cholesterol gallstones

被引：3
|
作者：
Nai-Qiang Cui
机构：
来源：
Hepatobiliary&PancreaticDiseasesInternational | 2005年 / 01期
关键词：
SCP2 mRNA expression; lithogenic biles; cholesterol gallstone;
D O I：
暂无
中图分类号：
R575.6 [胆囊疾病];
学科分类号：
摘要：
BACKGROUND: Hypersecretion of biliary cholesterol is believed to be one of the important causes of lithogenic bile. Sterol carrier protein-2 ( SCP2 ) participates in choles- terol trafficking and metabolism and may play a key role in cholesterol gallstone formation. This study was undertaken to investigate the expression of liver SCP2 mRNA in pa- tients with cholesterol gallstone and those patients with non-cholesterol gallstone. METHODS: The expression of liver SCP2 mRNA was studi- ed in 36 patients with cholesterol gallstone and 30 patients with non-cholesterol gallstone by reverse transcription-poly- merase chain reaction (RT-PCR). RESULT: The expression of SCP2 mRNA was increased more significantly in patients with cholesterol gallstone than in patients with non-cholesterol gallstone. CONCLUSION: The SCP2 gene was overexpressed in pa- tients with cholesterol gallstone, indicating that SCP2 may be one of the important causes of cholesterol gallstone.
引用
收藏
页码：117 / 120
页数：4
相关论文
共 50 条
  • [1] Overexpression of Sterol Carrier Protein 2 in Patients with Hereditary Cholesterol Gallstones
    Cui, YunFeng
    Li, ZhongLian
    Zhao, ErPeng
    Jia, YanFeng
    Li, DongHua
    Zhang, Ju
    Cui, NaiQiang
    BMC GASTROENTEROLOGY, 2011, 11
  • [2] Overexpression of Sterol Carrier Protein 2 in Patients with Hereditary Cholesterol Gallstones
    YunFeng Cui
    ZhongLian Li
    ErPeng Zhao
    YanFeng Jia
    DongHua Li
    Ju Zhang
    NaiQiang Cui
    BMC Gastroenterology, 11
  • [3] Overexpression of sterol carrier protein-2 differentially alters hepatic cholesterol accumulation in cholesterol-fed mice
    Atshaves, Barbara P.
    McIntosh, Avery L.
    Martin, Gregory G.
    Landrock, Danilo
    Payne, H. Ross
    Bhuvanendran, Shivaprasad
    Landrock, Kerstin K.
    Lyuksyutova, Olga I.
    Johnson, Jeffery D.
    Macfarlane, Ronald D.
    Kier, Ann B.
    Schroeder, Friedhelm
    JOURNAL OF LIPID RESEARCH, 2009, 50 (07) : 1429 - 1447
  • [4] Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion
    Baum, CL
    Reschly, EJ
    Gayen, AK
    Groh, ME
    Schadick, K
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) : 6490 - 6498
  • [5] Sterol carrier protein-2: Not just for cholesterol any more
    Murphy, EJ
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2002, 239 (1-2) : 87 - 93
  • [6] REGULATION OF MEMBRANE CHOLESTEROL DOMAINS BY STEROL CARRIER PROTEIN-2
    HAPALA, I
    KAVECANSKY, J
    BUTKO, P
    SCALLEN, TJ
    JOINER, CH
    SCHROEDER, F
    BIOCHEMISTRY, 1994, 33 (24) : 7682 - 7690
  • [7] PARTICIPATION OF STEROL CARRIER PROTEIN-2 IN CHOLESTEROL-METABOLISM
    KESAV, S
    MCLAUGHLIN, J
    SCALLEN, TJ
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1992, 20 (04) : 818 - 824
  • [8] CHOLESTEROL INTERACTION WITH RECOMBINANT HUMAN STEROL CARRIER PROTEIN-2
    COLLES, SM
    WOODFORD, JK
    MONCECCHI, D
    MYERSPAYNE, SC
    MCLEAN, LR
    BILLHEIMER, JT
    SCHROEDER, F
    LIPIDS, 1995, 30 (09) : 795 - 803
  • [9] Sterol carrier protein-2
    Seedorf, U
    Ellinghaus, P
    Nofer, JR
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1486 (01): : 45 - 54
  • [10] A potential role for sterol carrier protein-2 in cholesterol transfer to mitochondria
    Gallegos, AM
    Schoer, JK
    Starodub, O
    Kier, AB
    Billheimer, JT
    Schroeder, F
    CHEMISTRY AND PHYSICS OF LIPIDS, 2000, 105 (01) : 9 - 29
12345