U7 snRNAs:A Computational Survey

被引：0

作者：

Manja Marz

Axel Mosig

Brbel M.R.Stadler

Peter F.Stadler

机构：

[1] Austria Santa Fe Institute

[2] Bioinformatics Group Department of Computer Science

[3] CAS/MPG Partner Institute for Computational Biology

[4] China Max Planck Institute for Mathematics in the Sciences

[5] Chinese Academy of Sciences

[6] Department of Combinatorics and Geometry

[7] Germany

[8] Germany Department of Theoretical Chemistry

[9] Germany Fraunhofer Institute for Cell Therapy and Im-munology

[10] Germany Interdisciplinary Center for Bioin-formatics

[11] Leipzig D-04103

[12] Leipzig D-04107

[13] NM 87501

[14] Shang-hai Institutes for Biological Sciences

[15] Shanghai 200031

[16] USA.

[17] University of Leipzig

[18] University of Vienna

[19] Vienna A-1090

来源：

Genomics,Proteomics & Bioinformatics | 2007年 / Z1期

关键词：

U7; snRNA; non-coding RNA; RNA secondary structure; evolution;

D O I：

暂无

中图分类号：

Q75 [分子遗传学];

学科分类号：

071007 ;

摘要：

U7 small nuclear RNA (snRNA) sequences have been described only for a handful of animal species in the past. Here we describe a computational search for func-tional U7 snRNA genes throughout vertebrates including the upstream sequence elements characteristic for snRNAs transcribed by polymerase Ⅱ. Based on the results of this search,we discuss the high variability of U7 snRNAs in both se-quence and structure,and report on an attempt to find U7 snRNA sequences in basal deuterostomes and non-drosophilids insect genomes based on a combination of sequence,structure,and promoter features. Due to the extremely short se-quence and the high variability in both sequence and structure,no unambiguous candidates were found. These results cast doubt on putative U7 homologs in even more distant organisms that are reported in the most recent release of the Rfam database.

引用

页码：187 / 195

页数：9

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