High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases

被引：1

作者：

Mamie Gao ^{[1
]}

Allen Zhong ^{[1
]}

Neil Patel ^{[1
]}

Chiraag Alur ^{[1
]}

Dinesh Vyas ^{[1
]}

机构：

[1] Department of Surgery, Texas Tech University

来源：

World Journal of Gastroenterology | 2017年 / 16期

关键词：

Colon; RNA sequencing; Colon cancer; Transcriptome; Next generation sequencing; high throughput;

D O I：

暂无

中图分类号：

R574.62 [结肠疾病]; R730.43 [实验室诊断];

学科分类号：

1002 ; 100201 ; 100214 ;

摘要：

RNA sequencing is the use of hight hroughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differential expression of genes(DEG’s), mutated genes, fusion genes, and gene isoforms in disease states. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease(ulcerative colitis and Crohn’s disease), and irritable bowel syndrome.

引用

页码：2819 / 2825

页数：7

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