Efficient Synthesis of 2-Ethyl-A-ring Analogues of 19-Nor-1α,25-dihydroxy Vitamin D3

被引：0

作者：

WANG Qiu an 1

2. Department of Organic Chemistry

机构：

来源：

Chemical Research in Chinese Universities | 2003年 / 02期

关键词：

Ethyl; 19; nor; α; 25 dihydroxy vitamin D 3; Synthesis; Lipase catalyzed; Asymmetrization;

D O I：

暂无

中图分类号：

TQ466 [维生素制造];

学科分类号：

摘要：

The novel 19 nor l α ,25 dihydroxy vitamin D 3 analogues possessing an ethyl at the 2 position(4 and 5), were synthesized by coupling 25 hydroxy Windaus Grundmann ketone derivative 20 with A ring synthons(15 and 19) respectively. The enantioselective synthesis of substituted bicyclic hexanes structure A ring synthons, started from all cis 3,5 dihydroxy 4 ethyl 1 (methoxycarbonyl)cyclohexane via lipase catalyzd asymmetrization, was demonstrated.

引用

页码：165 / 173

页数：9

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