Synthesis and Cytotoxic Activity of Novel Water-soluble Prodrugs of Combretastatin A-4

被引：0
|
作者：
Zhi Quan YONG
机构：
来源：
Chinese Chemical Letters | 2006年 / 01期
关键词：
Combretastatin A-4; cytotoxicity; phosphoryl choline; water-soluble; prodrug;
D O I：
暂无
中图分类号：
TQ464 [生物制品药物的生产];
学科分类号：
100705 ;
摘要：
Novel water-soluble prodrugs of combretastatin A-4 (5-8) were synthesized and evaluated for their in vitro cytotoxicity against lung carcinoma A549. Compound 5, bearing phosphoryl choline (PC) moiety, showed 90% inhibition at 32 μg/mL concentration after 24 h. The findings showed the PC derivative would be a promising candidate for the development of new water-soluble prodrug of cytotoxic combretastatin A-4.
引用
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页码：23 / 26
页数：4
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