CRISPR/Cas9 system: a powerful technology for in vivo and ex vivo gene therapy

被引：0

作者：

Xiaohui Zhang ^{[1
]}

Liren Wang ^{[1
]}

Mingyao Liu ^{[1
]}

Dali Li ^{[1
]}

机构：

[1] Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University

来源：

Science China Life Sciences | 2017年 / 05期

基金：

中国国家自然科学基金;

关键词：

CRISPR/Cas9; gene therapy; in vivo; ex vivo;

D O I：

暂无

中图分类号：

R450 [];

学科分类号：

100215 ;

摘要：

CRISPR/Cas9 is a versatile genome-editing tool which is widely used for modifying the genome of both prokaryotic and eukaryotic organisms for basic research and applications. An increasing number of reports have demonstrated that CRISPR/Cas9-mediated genome editing is a powerful technology for gene therapy. Here, we review the recent advances in CRISPR/Cas9-mediated gene therapy in animal models via different strategies and discuss the challenges as well as future prospects.

引用

页码：468 / 475

页数：8

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