RNA-binding proteins in neurological diseases

被引：0

作者：

ZHOU HuaLin ^{[1
]}

MANGELSDORF Marie ^{[2
]}

LIU JiangHong ^{[1
]}

ZHU Li ^{[1
]}

WU Jane Y ^{[1
,3
]}

机构：

[1] Institute of Biophysics,Chinese Academy of Sciences

[2] Queensland Brain Institute, The University of Queensland,Brisbane

[3] Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center, Northwestern University Feinberg School of Medicine

来源：

Science China Life Sciences | 2014年 / 57卷 / 04期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

RNA-binding proteins; post-transcriptional regulation; neurological diseases;

D O I：

暂无

中图分类号：

R742 [脑部疾病];

学科分类号：

1002 ;

摘要：

Emerging studies support that RNA-binding proteins(RBPs)play critical roles in human biology and pathogenesis.RBPs are essential players in RNA processing and metabolism,including pre-mRNA splicing,polyadenylation,transport,surveillance,mRNA localization,mRNA stability control,translational control and editing of various types of RNAs.Aberrant expression of and mutations in RBP genes affect various steps of RNA processing,altering target gene function.RBPs have been associated with various diseases,including neurological diseases.Here,we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2,HuR/HuB/HuC/HuD,TDP-43,Fus,Rbfox1/Rbfox2,QKI and FMRP,discussing their function and roles in human diseases.

引用

页码：432 / 444

页数：13

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