Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease

被引:0
|
作者
Naoyuki Fujimori [1 ]
Takeji Umemura [1 ]
Takefumi Kimura [1 ]
Naoki Tanaka [2 ,3 ]
Ayumi Sugiura [1 ]
Tomoo Yamazaki [1 ]
Satoru Joshita [1 ]
Michiharu Komatsu [1 ]
Yoko Usami [4 ]
Kenji Sano [4 ]
Koji Igarashi [5 ]
Akihiro Matsumoto [1 ]
Eiji Tanaka [1 ]
机构
[1] Department of Internal Medicine,Division of Gastroenterology,Shinshu University School of Medicine
[2] Department of Metabolic Regulation,Shinshu University Graduate School of Medicine
[3] Research Center for Agricultural Food Industry,Shinshu University
[4] Department of Laboratory Medicine,Shinshu University Hospital
[5] Bioscience Division,TOSOH Corporation
关键词
Autotaxin; Non-alcoholic fatty liver disease; Fibrosis; Ballooning;
D O I
暂无
中图分类号
R575.5 [肝代谢障碍];
学科分类号
1002 ; 100201 ;
摘要
AIM To examine the relationship between serum autotaxin(ATX) concentrations and clinicopathological findings in non-alcoholic fatty liver disease(NAFLD) patients.METHODS One hundred eighty-six NAFLD patients who had undergone liver biopsy between 2008 and 2017 were retrospectively enrolled.Serum samples were collected at the time of biopsy and ATX was measured by enzyme immunoassays.Sera obtained from 160 healthy,nonobese individuals were used as controls.Histological findings were graded according to an NAFLD scoring system and correlations with serum ATX were calculated by Spearman’s test.Diagnostic accuracy was evaluated using the area under the receiver operating characteristic curve(AUC).Cut-off values were identified by the Youden index,and the nearest clinically applicable value to the cutoff was considered the optimal threshold for clinical convenience.RESULTS Serum ATX levels were significantly higher in NAFLD patients than in controls(0.86 mg/L vs 0.76 mg/L,P < 0.001) and correlated significantly with ballooning score and fibrosis stage(r = 0.36,P < 0.001 and r = 0.45,P < 0.001,respectively).Such tendencies were stronger in female patients.There were no remarkable relationships between ATX and serum alanine aminotransferase,lipid profiles,or steatosis scores.The AUC values of ATX for predicting the presence of fibrosis(≥ F1),significant fibrosis(≥ F2),severe fibrosis(≥ F3),and cirrhosis(F4),were all more than 0.70 in respective analyses.CONCLUSION Serum ATX levels may at least partially reflect histological severity in NAFLD.
引用
收藏
页码:1239 / 1249
页数:11
相关论文
共 50 条
  • [21] Serum amylase levels are decreased in Chinese non-alcoholic fatty liver disease patients
    Jinmei Yao
    Ying Zhao
    Juanwen Zhang
    Yani Hong
    Huanle Lu
    Jianping Wu
    Lipids in Health and Disease, 13
  • [22] The impact of alcohol consumption on hepatic fibrosis in non-alcoholic fatty liver disease
    Mitchell, T.
    Jeffrey, G. P.
    Macquillan, G.
    Garas, G.
    Ching, H.
    Hamdorf, J.
    Adams, L. A.
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2016, 31 : 110 - 111
  • [23] Serum adipokine levels in overweight patients and their relationship with non-alcoholic fatty liver disease
    Abenavoli, L.
    Luigiano, C.
    Guzzi, P. H.
    Milic, N.
    Morace, C.
    Stelitano, L.
    Consolo, P.
    Miraglia, S.
    Fagoonee, S.
    Virgilio, C.
    Luzza, F.
    De Lorenzo, A.
    Pellicano, R.
    PANMINERVA MEDICA, 2014, 56 (02) : 189 - 193
  • [24] Characterization of portal inflammation and hepatic fibrosis in non-alcoholic fatty liver disease
    Masters, Annie
    Estep, James M.
    Alaparthi, Lakshmi
    Bratthauer, Gary
    Birerdinc, Aybike
    Monge, Fanny
    Sharp, Cassandra
    Tan, Daisong
    Abdelaal, Hala
    Goodman, Zachary
    Younossi, Zobair
    JOURNAL OF HEPATOLOGY, 2023, 78 : S782 - S783
  • [25] The impact of alcohol consumption on hepatic fibrosis in non-alcoholic fatty liver disease
    Mitchell, Tim
    Jeffrey, Gary P.
    MacQuillan, Gerry C.
    Garas, George
    Ching, Helena
    Hamdorf, Jeffrey M.
    Adams, Leon A.
    HEPATOLOGY, 2016, 64 : 548A - 548A
  • [26] Serum uric acid levels and prognosis of patients with non-alcoholic fatty liver disease
    Yang, Xinyi
    Lin, Yan
    Huang, Jiaofeng
    Chi, Yujing
    Wu, Yinlian
    Lin, Su
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [27] Serum fetuin A/α2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: relation with liver fibrosis
    Yilmaz, Yusuf
    Yonal, Oya
    Kurt, Ramazan
    Ari, Ferda
    Oral, Arzu Yilmaztepe
    Celikel, Cigdem Ataizi
    Korkmaz, Seniz
    Ulukaya, Engin
    Ozdogan, Osman
    Imeryuz, Nese
    Avsar, Erol
    Kalayci, Cem
    ANNALS OF CLINICAL BIOCHEMISTRY, 2010, 47 : 549 - 553
  • [28] Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease
    Kumagai, Erina
    Mano, Yohei
    Yoshio, Sachiyo
    Shoji, Hirotaka
    Sugiyama, Masaya
    Korenaga, Masaaki
    Ishida, Tsuyoshi
    Arai, Taeang
    Itokawa, Norio
    Atsukawa, Masanori
    Hyogo, Hideyuki
    Chayama, Kazuaki
    Ohashi, Tomohiko
    Ito, Kiyoaki
    Yoneda, Masashi
    Kawaguchi, Takumi
    Torimura, Takuji
    Nozaki, Yuichi
    Watanabe, Sumio
    Mizokami, Masashi
    Kanto, Tatsuya
    SCIENTIFIC REPORTS, 2016, 6
  • [29] Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease
    Erina Kumagai
    Yohei Mano
    Sachiyo Yoshio
    Hirotaka Shoji
    Masaya Sugiyama
    Masaaki Korenaga
    Tsuyoshi Ishida
    Taeang Arai
    Norio Itokawa
    Masanori Atsukawa
    Hideyuki Hyogo
    Kazuaki Chayama
    Tomohiko Ohashi
    Kiyoaki Ito
    Masashi Yoneda
    Takumi Kawaguchi
    Takuji Torimura
    Yuichi Nozaki
    Sumio Watanabe
    Masashi Mizokami
    Tatsuya Kanto
    Scientific Reports, 6
  • [30] Elevated serum ferritin in non-alcoholic fatty liver disease is not predictive of fibrosis
    Trasolini, Roberto
    Cox, Ben
    Galts, Ciaran
    Yoshida, Eric M.
    Marquez, Vladimir
    CANADIAN LIVER JOURNAL, 2022, 5 (02): : 152 - 159