Recent advances in the identification of the host factors involved in dengue virus replication
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Yi Wang
[1
,2
]
Ping Zhang
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Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University
Key Laboratory of Tropical Diseases Control(Sun Yat-sen University), Ministry of EducationDepartment of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University
Ping Zhang
[1
,2
]
机构:
[1] Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University
[2] Key Laboratory of Tropical Diseases Control(Sun Yat-sen University), Ministry of Education
Dengue virus(DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation.Recent researches have indicated that a variety of host factors, including cellular proteins and micro RNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings(from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection.
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Osaka Med & Pharmaceut Univ, Res & Dev Ctr, Div Res Anim Lab & Translat Med, Takatsuki, JapanOsaka Med & Pharmaceut Univ, Res & Dev Ctr, Div Res Anim Lab & Translat Med, Takatsuki, Japan
Tanaka, Atsushi
Suzuki, Youichi
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Osaka Med & Pharmaceut Univ, Fac Med, Dept Microbiol & Infect Control, Takatsuki, JapanOsaka Med & Pharmaceut Univ, Res & Dev Ctr, Div Res Anim Lab & Translat Med, Takatsuki, Japan
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All India Inst Med Sci, Dept Biotechnol, New Delhi, IndiaAll India Inst Med Sci, Dept Biotechnol, New Delhi, India
Madhry, Deeksha
Malvankar, Shivani
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All India Inst Med Sci, Dept Biotechnol, New Delhi, IndiaAll India Inst Med Sci, Dept Biotechnol, New Delhi, India
Malvankar, Shivani
Phadnis, Sushant
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All India Inst Med Sci, Dept Biotechnol, New Delhi, IndiaAll India Inst Med Sci, Dept Biotechnol, New Delhi, India
Phadnis, Sushant
Srivastava, Rupesh K.
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All India Inst Med Sci, Dept Biotechnol, New Delhi, IndiaAll India Inst Med Sci, Dept Biotechnol, New Delhi, India
Srivastava, Rupesh K.
Bhattacharyya, Sankar
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Translat Hlth Sci & Technol Inst, NCR Biotech Sci Cluster, Faridabad, IndiaAll India Inst Med Sci, Dept Biotechnol, New Delhi, India
Bhattacharyya, Sankar
Verma, Bhupendra
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All India Inst Med Sci, Dept Biotechnol, New Delhi, India
All India Inst Med Sci, Dept Biotechnol, New Delhi 110029, IndiaAll India Inst Med Sci, Dept Biotechnol, New Delhi, India