The regulation of biothiol-responsive performance and bioimaging application of benzo[c][1,2,5]oxadiazole dyes

被引：4
|
作者：
Dongyang Li [1 ]
Weijie Chen [1 ]
Sheng Hua Liu [1 ]
Xiaoqiang Chen [2 ]
Jun Yin [1 ,2 ]
机构：
[1] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide andGreen Synthesis, International Joint Research Center for Intelligent Biosensing Technology and Health
[2] State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Jiangsu National Synergetic Innovation Center forAdvanced Materials (SICAM), Nanjing Tech University
来源：
Chinese Chemical Letters | 2020年 / 31卷 / 11期
基金：
中国国家自然科学基金;
关键词：
D O I：
暂无
中图分类号：
R318 [生物医学工程]; O657.3 [光化学分析法（光谱分析法）];
学科分类号：
070302 ; 081704 ; 0831 ;
摘要：
The different oxidation states of sulphur atom play a significant role on functional materials. In this work,a aryl-thioether and its sulphone substituted benzo[c][1,2,5]oxadiazole dyes were synthesized and utilized to determine thiol-containing amino acids. The result of selectivity experiments showed they detected the cysteine and homocysteine under physiological condition with negligible interference from other amino acids. In comparison to the thioether dye, the sulphone-based dye exhibited much faster response time for Cys and Hcy. However, the sulphone restricted its thiol-reactivity and bioimaging performance in living cells. By reducing the oxidation state of sulphur atom, we amazedly found that the sulfoxide-based dye still maintained high selectivity ultrafast response time for Cys/Hcy under physiological condition. It was worth mentioning that it also had high reactivity and good bioimaging performance that sulfone compounds did not have.
引用
收藏
页码：2891 / 2896
页数：6
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