Microspheres Sensor Based on Molecularly Imprinted Polymer Synthesized by Precipitation Polymerization

A new biomimetic bulk acoustic wave sensor based on molecularly imprinted microspheres (MIM) technique was described. The sensing materials were synthesized by precipitation polymerization. By using the Scatchard analysis, the equilibrium dissociation constant K D and the apparent maximum number Q max of the binding sites were calculated to be 3 70 mmol·L -1 and 9 11 μmol·g -1 , respectively. The sensor exhibited a sensitive response to the template compound (dipyridamole) in liquid phase with a detection limit of 2×10 -9 mol·L -1 . The recoveries of the sensor were 95 1%—105 4%. Studies presented in this paper show that the stability of this sensor is excellent. The sensor has been applied successfully to the determination of dipyridamole in human urine.