Three-dimensional cell culture models for investigating human viruses

被引:0
|
作者
Bing He [1 ]
Guomin Chen [1 ]
Yi Zeng [1 ]
机构
[1] State Key Laboratory of Infection Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
关键词
three-dimensional(3D) cell culture models; scaffolds; human viruses;
D O I
暂无
中图分类号
R373 [人体病毒学(致病病毒)];
学科分类号
100103 ; 100705 ;
摘要
Three-dimensional(3D) culture models are physiologically relevant, as they provide reproducible results, experimental flexibility and can be adapted for high-throughput experiments. Moreover,these models bridge the gap between traditional two-dimensional(2D) monolayer cultures and animal models. 3D culture systems have significantly advanced basic cell science and tissue engineering, especially in the fields of cell biology and physiology, stem cell research, regenerative medicine, cancer research, drug discovery, and gene and protein expression studies. In addition,3D models can provide unique insight into bacteriology, virology, parasitology and host-pathogen interactions. This review summarizes and analyzes recent progress in human virological research with 3D cell culture models. We discuss viral growth, replication, proliferation, infection, virus-host interactions and antiviral drugs in 3D culture models.
引用
收藏
页码:363 / 379
页数:17
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