Synthesis and spectroscopic characterization of novel 2-amino-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidine and pyrimido[1,2-α]pyrimidine derivatives

被引：0

作者：

Mohamed S.A.El-Gaby ^{[1
]}

Jehan A.Micky ^{[2
]}

Nadia M.Saleh ^{[2
]}

Yousry A.Ammar ^{[3
]}

Heba S.A.Mohamed ^{[4
]}

机构：

[1] Chemistry Department,Faculty of Science,Al-Azhar University at Assiut

[2] Chemistry Department,Faculty of Science (Girl’s),Al-Azhar University

[3] Chemistry Department,Faculty of Science,Al-Azhar University

[4] Photochemistry Department,National Research Center,El-Dokki,Giza,Egypt

来源：

Chinese Chemical Letters | 2015年 / 26卷 / 06期

关键词：

Multicomponent reaction Cyclopenta[d]pyrimidine Pyrimido[1; 2-α]pyrimidine Cyclopentanone;

D O I：

暂无

中图分类号：

O626.41 [间（二）氮苯（嘧啶）族];

学科分类号：

070303 ; 081704 ;

摘要：

2-Aminocyclopenta[d]pyrimidines 3a–c were achieved via a one-pot, three-component reactions of cyclopentanone 1, aromatic aldehyde and guanidine hydrochloride(1:2:1 molar ratio). Also, cyclization of 2,5-bis-(arylmethylidene)cyclopentanones 2 with guanidine hydrochloride(1:1 molar ratio) in methanol in the presence of sodium methoxide afforded cyclopenta-[d]pyrimidines 3. Compound 3c has been shown to be a useful building block for the synthesis of some novel pyrimido[1,2-a]pyrimidines 5, 7and 12. The structures of the newly synthesized compounds were confirmed on the basis of analytical and spectral data.

引用

页码：690 / 694

页数：5

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