Stage-specific localization of transforming growth factor β1 and β3 and their receptors during spermatogenesis in men

被引：0
|
作者：
Yuan-Qiang Zhang
机构：
来源：
Asian Journal of Andrology | 2004年 / 02期
关键词：
transforming growth factor; transforming growth factor receptors; human testis;
D O I：
暂无
中图分类号：
R321 [人体胚胎学（人体胎生学、发生学）];
学科分类号：
071008 ;
摘要：
Aim: To investigate the stage-specific localization of transforming growth factor (TGF) β1 and β3 during spermatogenesis in adult human testis. Methods: The localization of TGFβ1 and β3 was investigated by immunohis tochemical staining method employing specific polyclonal antibodies. Results: Both TGFβ1 and β3 and their recep tors were preponderant in the Leydig celis. TGFβ1 could not be detected in the seminiferous tubules. TGFβ3 and TGFβ-Receptor (R) I were mainly seen in the elongated spermatids, while TGFβ-RⅡ in the pachytene spermatocytes and weak in the spermatogonia, spermatids and Sertoli celis. Only TGFβ-RⅡ was detected in the Sertoli celis. TGFβ3, TGFβ-RⅠ and TGFβ-RⅡ showed a staining pattern dependent upon the stages of the seminiferous epithelium cycle. Conclusion: TGFβ isoforms and their receptors are present in the somatic and germ celis of the adult human testis, suggesting their involvement in the regulation of spermatogenesis.
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页码：105 / 109
页数：5
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