A Novel Angiotensin I Converting Enzyme Inhibitory Peptide from the Milk Casein:Virtual Screening and Docking Studies

被引：0
|
作者：
WANG Zhan-li2
机构：
来源：
AgriculturalSciencesinChina | 2011年 / 10卷 / 03期
基金：
国家高技术研究发展计划(863计划);
关键词：
novel angiotensin I converting enzyme; inhibitory peptide; virtual screening; docking;
D O I：
暂无
中图分类号：
R96 [药理学];
学科分类号：
100602 ; 100706 ;
摘要：
Angiotensin I converting enzyme (ACE) plays an important physiological role in the regulation of hypertension. In this study, we applied virtual screening to discover a novel angiotensin I converting enzyme inhibitory peptides from milk casein. One potential hit was identified based on docking scores, subsequently confirmed by activity studies in vitro (IC50=20.85 μmol L-1). The proposed peptide in this study contains a unique sequence, Lys-Val-Leu-Ile-Leu-Ala. Moreover, we performed the docking studies to understand the binding mode between the enzyme and peptide hit.
引用
收藏
页码：463 / 467
页数：5
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